SATB2 Antibody (SATBA4B10): sc-81376

SATB2 Antibody (SATBA4B10) is a mouse monoclonal IgG1 kappa light chain antibody that detects SATB2 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). Anti-SATB2 antibody (SATBA4B10) is available as a non-conjugated format. SATB2, or Special AT-rich sequence-binding protein 2, plays a crucial role in craniofacial development, particularly in jaw and palate formation, and is integral to a transcriptional network regulating skeletal development and osteoblast differentiation. SATB2 shows predominant expression in adult and fetal brain and features two CUT DNA-binding domains along with one homeobox domain, essential for gene regulation function. SATB2 shares close relation to SATB1, a known transcriptional repressor, and interacts with matrix-attachment regions (MARs) to modulate transcription of various genes, including HoxA2 and ATF4 (CREB-2), both vital for skeletal development. SATB2 functions as a transcriptional activator and repressor, serving as a protein scaffold that enhances activity of other DNA-binding proteins. Mutations in SATB2 can lead to cleft palate and are often associated with severe cognitive impairments, highlighting significance in both developmental biology and potential clinical implications.

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SATB2 Antibody (SATBA4B10) References:

1. Identification of SATB2 as the cleft palate gene on 2q32-q33.  |  FitzPatrick, DR., et al. 2003. Hum Mol Genet. 12: 2491-501. PMID: 12915443
2. SUMO modification of a novel MAR-binding protein, SATB2, modulates immunoglobulin mu gene expression.  |  Dobreva, G., et al. 2003. Genes Dev. 17: 3048-61. PMID: 14701874
3. Novel transcription factor Satb2 interacts with matrix attachment region DNA elements in a tissue-specific manner and demonstrates cell-type-dependent expression in the developing mouse CNS.  |  Britanova, O., et al. 2005. Eur J Neurosci. 21: 658-68. PMID: 15733084
4. Isolation and characterization of SATB2, a novel AT-rich DNA binding protein expressed in development- and cell-specific manner in the rat brain.  |  Szemes, M., et al. 2006. Neurochem Res. 31: 237-46. PMID: 16604441
5. SATB2 is a multifunctional determinant of craniofacial patterning and osteoblast differentiation.  |  Dobreva, G., et al. 2006. Cell. 125: 971-86. PMID: 16751105
6. Analysis of candidate genes on chromosome 2 in oral cleft case-parent trios from three populations.  |  Beaty, TH., et al. 2006. Hum Genet. 120: 501-18. PMID: 16953426
7. Satb2 haploinsufficiency phenocopies 2q32-q33 deletions, whereas loss suggests a fundamental role in the coordination of jaw development.  |  Britanova, O., et al. 2006. Am J Hum Genet. 79: 668-78. PMID: 16960803
8. Heterozygous nonsense mutation SATB2 associated with cleft palate, osteoporosis, and cognitive defects.  |  Leoyklang, P., et al. 2007. Hum Mutat. 28: 732-8. PMID: 17377962
9. Deregulation of SATB2 in carcinogenesis with emphasis on miRNA-mediated control.  |  Chen, QY., et al. 2019. Carcinogenesis. 40: 393-402. PMID: 30916759
10. SATB2 preserves colon stem cell identity and mediates ileum-colon conversion via enhancer remodeling.  |  Gu, W., et al. 2022. Cell Stem Cell. 29: 101-115.e10. PMID: 34582804
11. SATB2 expression in hematolymphoid neoplasms.  |  Tiu, GC., et al. 2023. J Hematop. 16: 119-122. PMID: 38175442
12. A MTA2-SATB2 chromatin complex restrains colonic plasticity toward small intestine by retaining HNF4A at colonic chromatin.  |  Gu, W., et al. 2024. Nat Commun. 15: 3595. PMID: 38678016

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-SATB2 Antibody (SATBA4B10) has 67 citations in a variety of scientific publications.

Primary antibodies like Anti-SATB2 Antibody (SATBA4B10) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

SATB2 Antibody (SATBA4B10) Specifications

Alternate Product Name: SATB Homeobox 2

Product Clone Name: SATBA4B10

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids:

Epitope Target: SATB2

Epitope Species: human

Product Reactivity/Detection: SATB2

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF

Vialing Information: Each vial contains 100 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 1.0% stabilizer protein

Research Citations: 67 citations in various scientific publications

Available Conjugates/Forms for SATB2 Antibody (SATBA4B10): N/A

The preferred SATB2 antibody is SATB2 Antibody (G-11): sc-518006.