In the intact cell, DNA closely associates with histones and other nuclear proteins to form chromatin. The remodeling of chromatin is believed to be a critical component of transcriptional regulation and a major source of this remodeling is brought about by the acetylation of nucleosomal histones. Acetylation of lysine residues in the amino terminal tail domain of histone results in an allosteric change in the nucleosomal conformation and an increased accessiblity to transcription factors by DNA. Conversely, the deacetylation of histones is associated with transcriptional silencing. Chromatin structure alteration may be brought about by the action of ATP-dependent multiprotein complexes. One such complex is the mSin3 corepressor complex, which contains mSin3, the histone deacetylases HDAC1 and HDAC2, the associated proteins SAP 30 and SAP 18, and the putative helicase Mi2.
Informations pour la commande
Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps SAP 18 (E-4) | sc-365376 | 200 µg/ml | $316.00 | |||
SAP 18 (E-4): m-IgG Fc BP-HRP Kit | sc-540333 | 200 µg Ab; 10 µg BP | $354.00 | |||
SAP 18 (E-4): m-IgG1 BP-HRP Kit | sc-542048 | 200 µg Ab; 20 µg BP | $354.00 | |||
Anticorps SAP 18 (E-4) X | sc-365376 X | 200 µg/0.1 ml | $316.00 |