Anticorps Rpp38 (B-6): sc-398113
- L'Anticorps Rpp38 (B-6) est un monoclonal de souris IgG2b (chaîne légère kappa) fourni en 200 µg/ml
- dirigé contre les acides aminés 205-246 situés près de la région C-terminus de Rpp38 d'origine human
- recommandé pour la détection de Rpp38 d'origine human par WB, IP, IF et ELISA
- 2b BP-HRP">m-IgG2b BP-HRP est le réactif de détection secondaire préféré pour l'anticorps Rpp38 (B-6) pour les applications WB. Ce réactif est désormais proposé en association avec l'anticorps Rpp38 (B-6)(voir les informations relatives à la commande ci-dessous).
Ribonuclease P (PNase P) and Ribonuclease MRP (RNase MRP) are small nuclear ribonucleoproteins (snRNPs) that act on RNA substrates in vitro. RNase P and RNase MRP, which accumulate in the nucleolus, have a similar RNA component and also have several protein subunits in common. RNase P, which consists of a complex of an RNA species (H1 RNA), POP1 (Processing of Precursor 1), POP5 (Processing of Precursor 5), and at least 7 Rpps (including Rpp14, Rpp29, Rpp30 and Rpp38), removes the 5-prime leader sequences from precursor tRNA molecules. In particular, the nucleolar-localizing RNase P catalyzes the hydrolysis of a specific phosphodiester bond in precursor tRNA to form the mature 5′ end of tRNA. The structurally related RNase MRP plays an essential role in the formation of the 5′ end of 5.8S rRNA. Both RNase P and RNase MRP are associated with Th/To ribonucleoproteins; Rpp30 and Rpp38 have specifically been implicated as Th autoantigens which contribute to the autoimmune disease systemic sclerosis.
Informations pour la commande
| Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps Rpp38 (B-6) | sc-398113 | 200 µg/ml | $316.00 | |||
Rpp38 (B-6): m-IgG2b BP-HRP Kit | sc-548626 | 200 µg Ab; 10 µg BP | $354.00 |