Ron β Antibody (E-3): sc-74588

Ron β Antibody (E-3) is a mouse monoclonal IgG1 kappa light chain antibody engineered to recognize amino acids 531-690 of the human Ron precursor, also known as MST1R, macrophage-stimulating protein receptor (MSP receptor), or CD136 antigen. Ron β is the transmembrane and intracellular domain of the Ron receptor tyrosine kinase, strategically located at the plasma membrane where Ron β plays a pivotal role in mediating signal transduction pathways that regulate essential cellular processes such as growth, survival, and migration. This precise localization is crucial as Ron β effectively interacts with extracellular ligands and downstream signaling molecules, thereby maintaining cellular homeostasis and enabling cells to respond appropriately to environmental stimuli. The proper functioning of Ron β is vital for normal cellular operations, and Ron β dysregulation is frequently implicated in the progression and metastasis of various cancers, making Ron β a significant target for both cancer research and therapeutic development. Ron β monoclonal antibody (E-3) exhibits exceptional specificity for human Ron β and is validated for use in western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA) applications, ensuring reliable detection and analysis across multiple experimental platforms. By targeting a conserved epitope within the Ron β subunit, anti-Ron β antibody (E-3) facilitates accurate quantification and characterization of Ron β expression and activation, enabling researchers to elucidate the mechanisms underlying Ron-mediated signaling pathways.

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Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Ron β Antibody (E-3) has 4 citations in a variety of scientific publications.

Primary antibodies like Anti-Ron β Antibody (E-3) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Ron β Antibody (E-3) Specifications

Alternate Product Name: Ron β

Product Clone Name: E-3

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 531-690

Epitope Target: the Ron precursor

Epitope Species: human

Product Reactivity/Detection: Ron β

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 4 citations in various scientific publications

Available Conjugates/Forms for Ron β Antibody (E-3): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin

The preferred Ron β antibody is Ron β Antibody (E-9): sc-374626.