Molecular structure of Ro 20-1724, CAS Number: 29925-17-5
Ro 20-1724 (CAS 29925-17-5)
See product citations (17)
Alternate Names:
4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone
Application:
Ro 20-1724 is a selective inhibitor of cAMP-specific phosphodiesterase
CAS Number:
29925-17-5
Purity:
≥98%
Molecular Weight:
278.35
Molecular Formula:
C15H22N2O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Ro 20-1724 is a selective inhibitor of cGMP-insensitive PDE4 (type IV phosphodiesterase, PDE IV) found in immune cells which increase endothelial cAMP levels and stabilize the endothelial barrier. In addition, Ro 20-1724 inhibits PDE3 (type III phosphodiesterase, PDE III) enzymes that form complexes with PDE4 enzymes in cardiac tissue. Studies show that Ro 20-1724, like other PDE4 inhibitors, suppresses the release of cytokines and other inflammatory signals as well as inhibits the development of oxygen reactive species.
Ro 20-1724 (CAS 29925-17-5) References
- Effect of vitamin E succinate and a cAMP-stimulating agent on the expression of c-myc and N-myc and H-ras in murine neuroblastoma cells. | Cohrs, RJ., et al. 1991. Int J Dev Neurosci. 9: 187-94. PMID: 1647646
- Differential effects of Ro 20-1724 and isobutylmethylxanthine on the basal force of contraction and beta-adrenoceptor-mediated response in the rat ventricular myocardium. | Katano, Y. and Endoh, M. 1990. Biochem Biophys Res Commun. 167: 123-9. PMID: 1689999
- Alpha 1-adrenergic regulation of thyrotropin-stimulated release of 3, 5, 3' -triiodothyronine and thyroxine from perifused mouse thyroid. | Oda, Y., et al. 1991. J Endocrinol Invest. 14: 867-73. PMID: 1724977
- Antipsychotic-like properties of phosphodiesterase 4 inhibitors: evaluation of 4-(3-butoxy-4-methoxybenzyl)-2-imidazolidinone (RO-20-1724) with auditory event-related potentials and prepulse inhibition of startle. | Halene, TB. and Siegel, SJ. 2008. J Pharmacol Exp Ther. 326: 230-9. PMID: 18420599
- Intravenously administered phosphodiesterase 4 inhibitors dilate retinal blood vessels in rats. | Miwa, T., et al. 2009. Eur J Pharmacol. 602: 112-6. PMID: 19027003
- Sphingosine and psychosine, suggested inhibitors of protein kinase C, inhibit LH effects in rat luteal cells. | Sender Baum, MG. and Ahrén, KE. 1988. Mol Cell Endocrinol. 60: 127-35. PMID: 2463943
- The identification of a new cyclic nucleotide phosphodiesterase activity in human and guinea-pig cardiac ventricle. Implications for the mechanism of action of selective phosphodiesterase inhibitors. | Reeves, ML., et al. 1987. Biochem J. 241: 535-41. PMID: 3036066
- Effect of alpha tocopheryl succinate on adenylate cyclase activity in murine neuroblastoma cells in culture. | Sahu, SN., et al. 1988. J Am Coll Nutr. 7: 285-93. PMID: 3209780
- Structure-activity relationships for inhibitors of phosphodiesterase from erythrocytes and other tissues. | Sheppard, H., et al. 1972. Adv Cyclic Nucleotide Res. 1: 103-12. PMID: 4354559
- In vivo effects of apomorphine and 4-(3-butoxy-4-methoxybenzyl)-2-imidazolidinone (RO 20-1724) on cyclic nucleotides in rat brain and pituitary. | Kant, GJ., et al. 1980. Biochem Pharmacol. 29: 369-73. PMID: 6244838
- Effects of cyclic AMP analogues and phosphodiesterase inhibitors on K+-induced [3H]noradrenaline release from rat brain slices and on its presynaptic alpha-adrenergic modulation. | Wemer, J., et al. 1982. J Neurochem. 39: 349-56. PMID: 6283025
- The effects of theophylline and 4-(3-butoxy-4-methoxybenzyl)-2-imidazolidinone (RO 20-1724) on protein secretion from rat parotid gland. | Afari, G., et al. 1982. Br J Pharmacol. 77: 405-11. PMID: 6291691
- The effects of alkylated xanthines on cyclic AMP accumulation in dog thyroid slices exposed to carbamylcholine. | Miot, F., et al. 1984. Mol Pharmacol. 25: 261-6. PMID: 6321949
- Effect of vascular smooth muscle relaxants on the protein kinase C-mediated contraction in the rat pulmonary artery. | Savineau, JP., et al. 1993. Eur J Pharmacol. 249: 191-8. PMID: 8287900
- Increased expression of ubiquitin during adenosine 3',5'-cyclic monophosphate-induced differentiation of neuroblastoma cells in culture. | La Rosa, FG., et al. 1996. J Neurochem. 66: 1845-50. PMID: 8780009
Inhibitor of:
HHV-4 EBNA-2, OR1D5, and PDE3A.Activator of:
ACN9, CELF3, CSDA, GALR1, IGFL1, MPP3, PDE, Presenilin 2, RBM3, and Zic2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Ro 20-1724, 100 mg | sc-200709 | 100 mg | $87.00 | |||
Ro 20-1724, 1 g | sc-200709A | 1 g | $426.00 | |||
Ro 20-1724, 5 g | sc-200709B | 5 g | $1574.00 |