Rheb Antibody (80-R): sc-130398
- Rheb Antibody (80-R) is a mouse monoclonal IgG1 κ, cited in 6 publications, provided at 100 µg/ml
- raised against recombinant Rheb of human origin
- recommended for detection of Rheb of mouse, rat and human origin by WB and IP
- See Rheb (B-12): sc-271509 for Rheb antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for Rheb Antibody (80-R) for WB applications. These reagents are now offered in bundles with Rheb Antibody (80-R) (see ordering information below).
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Rheb Antibody (80-R) is a mouse monoclonal IgG1 kappa light chain antibody that detects Rheb in mouse, rat, and human samples through western blotting (WB) and immunoprecipitation (IP). Anti-Rheb antibody (80-R) is available in a non-conjugated form, allowing for versatile applications in research. Rheb, or Ras homolog enriched in brain, plays a crucial role in cellular signaling pathways, particularly in the regulation of mTOR (mechanistic target of rapamycin) signaling, which is vital for cell growth, proliferation, and survival. Rheb is primarily located in the cytoplasm and can translocate to the lysosome, where Rheb interacts with mTORC1 (mTOR complex 1) to promote anabolic processes. This localization is significant because Rheb integrates signals from growth factors and nutrient availability, thereby influencing cellular metabolism and growth. Dysregulation of Rheb and associated signaling pathways has been implicated in various cancers and metabolic disorders, making Rheb an important target for therapeutic intervention. Rheb monoclonal antibody (80-R) is an essential tool for researchers studying these critical pathways and their implications in health and disease.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Rheb Antibody (80-R) References:
- Rheb in neuronal degeneration, regeneration, and connectivity. | Potheraveedu, VN., et al. 2017. Biol Chem. 398: 589-606. PMID: 28212107
- Mechanisms of mTORC1 activation by RHEB and inhibition by PRAS40. | Yang, H., et al. 2017. Nature. 552: 368-373. PMID: 29236692
- Ubiquitination of Rheb governs growth factor-induced mTORC1 activation. | Deng, L., et al. 2019. Cell Res. 29: 136-150. PMID: 30514904
- Upregulation of Neuronal Rheb(S16H) for Hippocampal Protection in the Adult Brain. | Moon, GJ., et al. 2020. Int J Mol Sci. 21: PMID: 32188096
- Disruption of neuronal RHEB signaling impairs oligodendrocyte differentiation and myelination through mTORC1-DLK1 axis. | Huang, H., et al. 2023. Cell Rep. 42: 112801. PMID: 37463107
- Small G-Protein Rheb Gates Mammalian Target of Rapamycin Signaling to Regulate Morphine Tolerance in Mice. | Wang, W., et al. 2024. Anesthesiology. 140: 786-802. PMID: 38147625
- The rapid proximity labeling system PhastID identifies ATP6AP1 as an unconventional GEF for Rheb. | Feng, R., et al. 2024. Cell Res. 34: 355-369. PMID: 38448650
- Glucose deprivation triggers DCAF1-mediated inactivation of Rheb-mTORC1 and promotes cancer cell survival. | Li, M., et al. 2024. Cell Death Dis. 15: 409. PMID: 38862475
- IL-37d suppresses Rheb-mTORC1 axis independently of TCS2 to alleviate alcoholic liver disease. | Chen, N., et al. 2024. Commun Biol. 7: 756. PMID: 38907105
- Dihydroberberine alleviates Th17/Treg imbalance in premature ovarian insufficiency mice via inhibiting Rheb/mTOR signaling. | Deng, D., et al. 2024. Mol Med. 30: 194. PMID: 39472803
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Rheb Antibody (80-R) | sc-130398 | 100 µg/ml | $339.00 | |||
Rheb Antibody (80-R): m-IgG Fc BP-HRP Bundle | sc-537331 | 100 µg Ab; 10 µg BP | $361.00 | |||
Rheb Antibody (80-R): m-IgGκ BP-HRP Bundle | sc-534572 | 100 µg Ab; 40 µg BP | $361.00 | |||
Rheb Antibody (80-R): m-IgG1 BP-HRP Bundle | sc-545140 | 100 µg Ab; 20 µg BP | $361.00 |