Anticorps Ran BP-M (A-5): sc-271726
- L'Anticorps Ran BP-M (A-5) est un monoclonal de souris IgG2a (chaîne légère kappa) fourni en 200 µg/ml
- spécifique d'un épitope situé entre les acides aminés 345-371 près de N-terminus de Ran BP-M d'origine human
- recommandé pour la détection de Ran BP-M isoform 1 d'origine mouse, rat et human par WB, IP, IF, IHC(P) et ELISA
- Nous testons actuellement encore nos anticorps secondaires pour trouver la meilleure protéine de liaison pour cet anticorps primaire Ran BP-M (A-5). Veuillez nous contacter si vous avez des questions concernant les réactifs de détection secondaire appropriés.
The small Ras-related protein Ran, also designated TC4, is a nuclear localized GTPase implicated in a diverse array of cellular processes including DNA replication, entry into and exit from mitosis, and the transport of RNA and proteins through the nuclear pore complex. Like Ras, active Ran GTP and inactive Ran GDP levels are tightly regulated by guanine nucleotide exchange factors (GEFs) and GTPase activating proteins (GAPs). Ran BP-M, also designated Ran-binding protein 9, is involved the nucleation of microtubule networks and may also act as an adapter protein in the coupling of membrane receptors to intracellular signaling pathways. It has been implicated in the activation of androgen and glucocorticoid receptor. Ran BP-M contains phosphorylated Serine residues. It can localize to both the nucleus and the cytoplasm, and a phosphorylated form can be associated with the plasma membrane. Ran BP-M is ubiquitously expressed, with highest expression levels in heart, testis, muscle and placenta. The enzymatic activity of the Ran BP-M protein is associated with breast cancer progression and fragile-X mental retardation.
Informations pour la commande
| Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps Ran BP-M (A-5) | sc-271726 | 200 µg/ml | $316.00 | |||
Ran BP-M (A-5) peptide neutralisant | sc-271726 P | 100 µg/0.5 ml | $68.00 |