ACCÈS RAPIDE AUX LIENS
The carboxy-terminal of rabphilin-3A consists of two C2 domains, A and B, and the amino-terminal (residues 45-170) contains a cysteine-rich rich region with two zinc finger motifs. Rabphilin-3A belongs to a family of other carboxy-terminal type (C-type) tandem C2 proteins, which includes synaptotagmins and Doc2. Rabphilin is expressed in neuroendocrine cells and co-localizes with Rab3A on synaptic vesicles and chromaffin granules. Rabphilin-3A binds Rab3a/GTP/Mg+ within amino-terminal residues 45 and 170. Rabphilin-3A binds calcium ions and phosphatidylinositol 4,5-bisphophate containing lipid vesicles within its C2 domains. Rabphilin-3A is a positive regulator of calcium dependent exocytosis, while Rab3a is a negative regulator of exocytosis. Although rabphilin-3A associates with Rab3a, they seem to influence exocytosis independently of each other. Rabphilin-3A effects are likely mediated through interactions with an unknown factor that recognizes the Rab3 binding domain.
Informations pour la commande
Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps rabphilin-3A (E-2) | sc-390915 | 200 µg/ml | $316.00 | |||
rabphilin-3A (E-2): m-IgG Fc BP-HRP Kit | sc-538113 | 200 µg Ab; 10 µg BP | $354.00 | |||
rabphilin-3A (E-2): m-IgGκ BP-HRP Kit | sc-535664 | 200 µg Ab; 40 µg BP | $354.00 | |||
rabphilin-3A (E-2): m-IgG1 BP-HRP Kit | sc-545529 | 200 µg Ab; 20 µg BP | $354.00 |