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Anticorps Rab 5C (D-6): sc-374041

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Fiches techniques
  • L'Anticorps Rab 5C (D-6) est un monoclonal de souris IgG1 κ, cité dans 1 publications, fourni en 200 µg/ml
  • spécifique d'un épitope situé entre les acides aminés 186-216 au niveau C-terminus de Rab 5C d'origine human
  • recommandé pour la détection de Rab 5C d'origine mouse, rat et human par WB, IP, IF et ELISA; également réactif avec d'autres espèces, dont et equine, bovine and porcine
  • Voir Rab 5 (D-11): sc-46692 pour d'autres anticorps conjugués Rab 5C, dont AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 et 790.
  • m-IgG Fc BP-HRP et m-IgG1 BP-HRP sont les réactifs de détection secondaire préférés pour Rab 5C Antibody (D-6) for WB applications. Ces réactifs sont désormais proposés en lots avec Rab 5C Antibody (D-6)(voir les informations de commande ci-dessous).
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The Ras-related superfamily of guanine nucleotide binding proteins, which includes the R-Ras, Rap, Ral/Rec and Rho/Rab subfamilies, exhibit 30-60% homology with Ras p21. Accumulating data suggests an important role for Rab proteins, either in endocytosis or in biosynthetic protein transport. The transport of newly synthesized proteins from the endoplasmic reticulum to various stacks of the Golgi complex and to secretory vesicles involves at each stage the movement of carrier vesicles, a process that appears to involve Rab protein function. The possibility that Rab proteins might also direct the exocytosis from secretory vesicles to the plasma membrane is supported by the observation that in yeast, the SEC4 protein, which is 40% homologous to Rab proteins, is associated with secretory vesicles. At least eight members of the Rab subfamily have been identified, each of which is found at a particular stage of a membrane transport pathway.

Pour la Recherche Uniquement. Non destiné à un usage diagnostique ou thérapeutique.

Alexa Fluor® est une marque déposée de Molecular Probes Inc., OR., USA

LI-COR® et Odyssey® sont marques déposées de LI-COR Biosciences

Anticorps Rab 5C (D-6) Références:

  1. Las isoformas Rab5 orquestan una «división del trabajo» en la red endocítica; Rab5C modula la motilidad celular mediada por Rac.  |  Chen, PI., et al. 2014. PLoS One. 9: e90384. PMID: 24587345
  2. Régulation à la baisse de l'endocytose et de la glycolyse dépendantes de la protéine liée à Ras Rab 5C dans les lignées cellulaires de cancer de l'ovaire résistantes au cisplatine.  |  Jin, L., et al. 2014. Mol Cell Proteomics. 13: 3138-51. PMID: 25096996
  3. Rab5C aumenta la resistencia a la radiación ionizante en el cáncer rectal.  |  Baptistella, AR., et al. 2019. J Mol Med (Berl). 97: 855-869. PMID: 30968159
  4. El tráfico endocítico mediado por Rab5c regula el desarrollo de las células madre y progenitoras hematopoyéticas a través de la señalización Notch y AKT.  |  Heng, J., et al. 2020. PLoS Biol. 18: e3000696. PMID: 32275659
  5. RAB5C, una nueva diana de unión al ARNm de HuR, regula la proliferación de las células del cáncer de mama.  |  Wang, Z., et al. 2023. Cell Biol Int. 47: 374-382. PMID: 36480789
  6. Organización cromosómica no Rabl en núcleos endorreduplicados de tejidos de embrión y endospermo de cebada.  |  Nowicka, A., et al. 2023. J Exp Bot. 74: 2527-2541. PMID: 36705553
  7. El etiquetado click selectivo de orgánulos acoplado a la citometría de flujo permite el cribado CRISPR agrupado de genes implicados en el metabolismo de la fosfatidilcolina.  |  Tsuchiya, M., et al. 2023. Cell Metab. 35: 1072-1083.e9. PMID: 36917984
  8. Organización del genoma nuclear en los hongos: del plegamiento de genes a los cromosomas Rabl.  |  Torres, DE., et al. 2023. FEMS Microbiol Rev. 47: PMID: 37197899
  9. Macrocefalia y retraso del desarrollo causados por variantes missense en RAB5C.  |  Koop, K., et al. 2023. Hum Mol Genet. 32: 3063-3077. PMID: 37552066
  10. Rab5c promueve la replicación del VRS y el ADV mediante la autofagia en células epiteliales respiratorias.  |  Wang, X., et al. 2024. Virus Res. 341: 199324. PMID: 38242290

Informations pour la commande

Nom du produitRef. CatalogueCOND.Prix HTQTÉFavoris

Anticorps Rab 5C (D-6)

sc-374041
200 µg/ml
$322.00

Rab 5C (D-6): m-IgG Fc BP-HRP Kit

sc-540416
200 µg Ab; 10 µg BP
$361.00

Rab 5C (D-6): m-IgG1 BP-HRP Kit

sc-542106
200 µg Ab; 20 µg BP
$361.00

Rab 5C (D-6) peptide neutralisant

sc-374041 P
100 µg/0.5 ml
$69.00

Hi, I am looking for the anti-Rab5c antibody. Protein of my interest i.e XP_014048348.1 has 90% identity to given protein for the human Rab5c. I was wonderning if I can use this antibody for protein of my interest. What would you suggest?

Posée par: Anep
Thank you for your question. There is not significant sequence identity shared between this antibody’s antigen and the predicted protein sequence you provided so we would not expect cross-reactivity. One possible alternative antibody, Rab 5 Antibody (D-11): sc-46692, is raised against amino acids 1-215 full length Rab 5A. There is 83% sequence identity shared with the predicted protein sequence you provided. This is significant, and the antibody may be able to detect the protein in your Salmon samples. However, since this is a monoclonal antibody, the alignment would need to be 100% for us to be guarantee reactivity.
Répondue par: Technical Support
Date de publication: 2019-04-13

What application is the blocking peptide sc-374041 P appropriate for?

Posée par: Cweed
Thank you for your question. The blocking peptide is intended for use as a negative control, by pre-adsorbing the mouse monoclonal antibody against the antigen. For full protocol details, please contact our Technical Services Department or view our online protocol here: https://www.scbt.com/scbt/resources/protocols/peptide-neutralization
Répondue par: Technical Support
Date de publication: 2017-02-25
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Rated 5 de 5 de SH par Great monoclonal antibodyGreat monoclonal antibody, good specificity and strong signal strength for WB in mouse Rab 5C transfected 293T lysate. -SCBT QC
Date de publication: 2013-03-15
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Anticorps Rab 5C (D-6) est évalué 4.5 de 5 de 2.
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