Anticorps Quinidine (504): sc-57992

Quinidine is a class I antiarrhythmic agent first obtained from the bark of the cinchona tree. It is a stereoisomer of quinine that functions by blocking the fast inward sodium current, causing the phase 0 depolarization of the cardiac action potential to decrease and prolonging the cardiac action potential, thereby prolonging the QT interval on the surface EKG. Quinidine also blocks the slowly inactivating tetrodotoxin-sensitive sodium current, the slow inward calcium current, the rapid and slow components of the delayed potassium rectifier current, the inward potassium rectifier current, and the ATP-sensitive potassium channel. Quinidine inhibits the cytochrome P450 enzyme 2D6, and it may lead to increased blood levels of lidocaine, Beta blockers, opioids, and some antidepressants. Quinidine has a half life of six to eight hours, a molecular weight of 324.417 g/mol, and is metabolized in the liver by the cytochrome P450 system.