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PTF1, also known as PTF1A (pancreas specific transcription factor, 1A) or PTF1-p48, is a pancreas-specific protein that functions as a component of the trimeric pancreas transcription factor 1 (PTF1) complex. Localizing to the nucleus, PTF1 contains one basic helix-loop-helix (bHLH) domain and is believed to play an important role in mammalian pancreatic development, functioning as a transcription factor that regulates the specification of all three pancreatic cell types. PTF1 interacts with RBP-Jκ and, together, they cooperate in regulating the expression of PDX-1 (pancreas/duodenum homeobox protein 1), a key regulator of pancreatic islet development and insulin gene transcription in beta-cells. Loss of functional PTF1 can cause pancreatic progenitors to take on the normal fates of duodenal epithelia. Mutations in the gene encoding PTF1 lead to diabetes mellitus and cerebellar hypoplasia/agenesis, suggesting that PTF1 also plays and important role in cerebellar neurogenesis.
Informations pour la commande
Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps PTF1 (F-6) | sc-390519 | 200 µg/ml | $316.00 | |||
PTF1 (F-6): m-IgG Fc BP-HRP Kit | sc-540807 | 200 µg Ab; 10 µg BP | $354.00 | |||
PTF1 (F-6): m-IgG1 BP-HRP Kit | sc-542382 | 200 µg Ab; 20 µg BP | $354.00 | |||
PTF1 (F-6) peptide neutralisant | sc-390519 P | 100 µg/0.5 ml | $68.00 | |||
Anticorps PTF1 (F-6) X | sc-390519 X | 200 µg/0.1 ml | $316.00 |