In eukaryotic cells, selective breakdown of cellular proteins is ensured by their ubiquitination and subsequent degradation by the 26S Proteasome. The 26S Proteasome is a protease complex that selectively breaks down proteins that have been modified by polyubiquitin chains. It is made up of two multisubunit complexes: the 20S Proteasome chamber, which serves as the proteolytic core of the complex, and two 19S regulatory particles which recognize and unfold ubiquitinated proteins. The 20S Proteasome chamber contains α subunits (which are structural) and β subunits (which are predominantly catalytic). The outer two rings in the proteasome consist of seven α subunits each, and the inner two rings each consist of seven β subunits. PSMB11 (Proteasome subunit beta type-11), also known as BETA5T (Proteasome subunit beta-5t) is a 300 amino acid protein that plays an important role in CD8-positive T-cells and reduces chymotripsin-like activity in proteasomes.
Informations pour la commande
Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps PSMB11 (A-5) | sc-514317 | 200 µg/ml | $316.00 | |||
PSMB11 (A-5) peptide neutralisant | sc-514317 P | 100 µg/0.5 ml | $68.00 |