Anticorps PRX (A-6): sc-137150

The peroxiredoxin (PRX) family comprises six antioxidant proteins, PRX I, II, III, IV, V and VI, which protect cells from reactive oxygen species (ROS) by preventing the metal-catalyzed oxidation of enzymes. The PRX proteins primarily utilize thioredoxin as the electron donor for antioxidation, although they are fairly promiscuous with regard to the hydroperoxide substrate. In addition to protection from ROS, peroxiredoxins are also involved in cell proliferation, differentiation and gene expression. PRX I, II, IV and VI show diffuse cytoplasmic localization, while PRX III and V exhibit distinct mitochondrial localization. The human PRX I gene encodes a protein that is expressed in several tissues, including liver, kidney, testis, lung and nervous system. PRX II is expressed in testis, while PRX III shows expression in lung. PRX I, II and III are overexpressed in breast cancer and may be involved in its development or progression. Upregulated protein levels of PRX I and II in Alzheimer's disease (AD) and Down syndrome (DS) indicate the involvement of PRX I and II in their pathogenesis. The human PRX IV gene is abundantly expressed in many tissues. PRX IV exists as a precursor protein, which is only detected in testis, and a processed secreted form. PRX V also exists as two forms, designated long and short. Like PRX IV, the long form of PRX V is highly expressed in testis. The short form of PRX V is more widely expressed, with high expression in liver, kidney, heart and lung. PRX VI, a 1-Cys peroxiredoxin (also known as antioxidant protein 2 or AOP2), is highly expressed in most tissues, particularly in epithelial cells. Localized to the cell cytosol, PRX VI functions independently of other peroxiredoxins and antioxidant proteins, specializing in antioxidant defense, lung phospholipid metabolism and protection of keratinocytes from cell death induced by reactive oxygen species.

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Anticorps PRX (A-6) Références:

1. Interactions protéine-protéine au sein des systèmes de peroxiredoxine.  |  Noguera-Mazon, V., et al. 2006. Photosynth Res. 89: 277-90. PMID: 17089212
2. Les protéines de réparation de la peroxiredoxine.  |  Jönsson, TJ. and Lowther, WT. 2007. Subcell Biochem. 44: 115-41. PMID: 18084892
3. Une introduction à la biochimie de la peroxiredoxine.  |  Karplus, PA. 2015. Free Radic Biol Med. 80: 183-90. PMID: 25452140
4. Approches cinétiques de la mesure de la réactivité de la peroxiredoxine.  |  Winterbourn, CC. and Peskin, AV. 2016. Mol Cells. 39: 26-30. PMID: 26813658
5. Implication de la peroxiredoxine dans l'initiation et la progression du cancer humain.  |  Hampton, MB., et al. 2018. Antioxid Redox Signal. 28: 591-608. PMID: 29237274
6. Autophagie activée par la peroxiredoxine d'Entamoeba histolytica.  |  Li, X., et al. 2020. Cells. 9: PMID: 33198056
7. Peroxiredoxine, sénescence et cancer.  |  Wu, M., et al. 2022. Cells. 11: PMID: 35681467
8. Le célastrol supprime le cancer colorectal en ciblant de manière covalente la peroxiredoxine 1.  |  Xu, H., et al. 2023. Signal Transduct Target Ther. 8: 51. PMID: 36732502
9. La peroxiredoxine 6 supprime la ferroptose dans les cellules endothéliales pulmonaires.  |  Torres-Velarde, JM., et al. 2024. Free Radic Biol Med. 218: 82-93. PMID: 38579937
10. Une approche physiologique pour explorer comment la thiorédoxine-glutathion réductase (TGR) et la peroxiredoxine (Prx) éliminent H2O2 dans les cysticerques de Taenia.  |  Guevara-Flores, A., et al. 2024. Antioxidants (Basel). 13: PMID: 38671892

L'anticorps PRX préféré est l'Anticorps PRX (B-11): sc-137222.