Date published: 2025-9-10

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Anticorps PrP (6G3): sc-52969

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Fiches techniques
  • L'anticorps PrP 6G3 est un monoclonal IgG1 de souris fourni en 50 µg/0.5 ml
  • dirigé contre les acides aminés 130-150 de d'origine human
  • recommandé pour la détection de PrP d'origine mouse, rat, human, bovine, ovine et deer par WB et IP
  • Voir PrP (5B2): sc-47730 pour d'autres anticorps conjugués PrP, dont AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 et 790.
  • Nous testons actuellement encore nos anticorps secondaires pour trouver la meilleure protéine de liaison pour cet anticorps primaire PrP (6G3). Veuillez nous contacter si vous avez des questions concernant les réactifs de détection secondaire appropriés.

    ACCÈS RAPIDE AUX LIENS

    VOIR ÉGALEMENT...

    Prion diseases, or transmissible spongiform encephalopathies (TSEs), are manifested as genetic, infectious or sporadic, lethal neurodegenerative disorders involving alterations of the prion protein (PrP). Characteristic of prion diseases, cellular PrP (PrPc) is converted to the disease form, PrPSc, through alterations in the protein folding conformations. PrPc is constitutively expressed in normal adult brain and is sensitive to proteinase K digestion, while the altered PrPSc conformation is resistant to proteases, resulting in a distinct molecular mass after PK treatment. Consistent with the transient infection process of prion diseases, incubation of PrPc with PrPSc both in vitro and in vivo produces PrPc that is resistant to protease degradation. Infectious PrPSc is found at high levels in the brains of animals affected by TSEs, including scrapie in sheep, BSE in cattle and Cruetzfeldt-Jakob disease in humans.

    Pour la Recherche Uniquement. Non destiné à un usage diagnostique ou thérapeutique.

    Informations pour la commande

    Nom du produitRef. CatalogueCOND.Prix HTQTÉFavoris

    Anticorps PrP (6G3)

    sc-52969
    50 µg/0.5 ml
    $316.00

    I am using PrP (6G3): sc-52969 antibody for immunoprecipitation, how much antibody should I use?

    Posée par: jenniferc
    Thank you for your question. We recommend using 1–10 µl (i.e., 0.2–2 µg) of antibody with 1 ml of cell lysate. However, optimal antibody concentration should be determined by titration. Please find our full immunoprecipitation protocol here: https://www.scbt.com/scbt/resources/protocols/immunoprecipitation-western-blots
    Répondue par: Technical Support
    Date de publication: 2017-03-24
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    Rated 4 de 5 de par Robust band seen in WB using mouse brainRobust band seen in WB using mouse brain tissue extract. -SCBT QC
    Date de publication: 2015-05-12
    Rated 4 de 5 de par Bands seen in WB using humanBands seen in WB using human, bovine, sheep and deer recombinant PrP fusion protein. -SCBT QC
    Date de publication: 2014-10-29
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    Anticorps PrP (6G3) est évalué 4.0 de 5 de 2.
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