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Prostasin, a serine protease first identified in prostate tissue, activates epithelial sodium channels in a variety of tissues. Though typically a membrane-anchored protein, free prostasin is also found in physiologic fluids and tissue culture media, indicating a mechanism for secretion from the cells as well. Aprotinin and other protease inhibitors suppress the channel-activating capacity of prostasin, while aldosterone increases prostasin expression and stimulates sodium uptake. In addition, DNA methylation negatively correlates with prostasin expression in cancer cells, while enforced reexpression decreases invasiveness as well as metastatic potential, implying that prostasin activity reflects epithelial cell physiology.
Informations pour la commande
Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps Prostasin (2) | sc-136272 | 200 µg/ml | $316.00 | |||
Prostasin (2): m-IgG Fc BP-HRP Kit | sc-539905 | 200 µg Ab; 10 µg BP | $354.00 | |||
Prostasin (2): m-IgG2a BP-HRP Kit | sc-546815 | 200 µg Ab; 10 µg BP | $354.00 |