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Peroxisome proliferator-activated receptor-interacting protein (PRIP), also designated nuclear receptor co-activator 6, is related to Phospholipase C, but is catalytically inactive on its own. It acts as a nuclear receptor co-activator by binding directly to nuclear receptors and stimulating their transcriptional activities in a hormone-dependent manner. PRIP is a ubiquitously expressed protein with highest expression in ovary, brain, testis and prostate. It interacts with PRIP-interacting protein with methyltransferase activity (PIMT). They serve as liaisons between cAMP response element-binding protein-binding protein (CBP) and PPARγ-binding protein-anchored (PBP) co-activator complexes, which are involved in the transcriptional activity of nuclear receptors. PRIP also plays an important role in controlling the action of GABAA receptor phosphorylation by inhibiting phosphatase PP1, thereby mediating the action of synaptic inhibition that is controlled by these receptors.
Informations pour la commande
Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps PRIP (39-Q) | sc-101129 | 100 µg/ml | $333.00 |