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Praziquantel (CAS 55268-74-1)

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Alternate Names:
(±)-Praziquantel
Application:
Praziquantel is a highly effective anthelmintic
CAS Number:
55268-74-1
Purity:
≥98%
Molecular Weight:
312.41
Molecular Formula:
C19H24N2O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Praziquantel is a synthetic compound widely utilized in research, particularly in the field of parasitology. Its action mechanism involves disruption of the calcium ion homeostasis within parasitic worms, leading to muscle paralysis and eventual death of the parasite. As a research tool, praziquantel is instrumental in studying schistosome biology, and it offers insights into potential mechanisms for controlling invasive species in aquatic environments. Investigations into its mode of action have furthered the understanding of calcium channels in invertebrates, providing a foundational model for exploring similar targets in other organisms. Additionally, environmental scientists employ praziquantel in ecosystem studies to assess the impact of parasitic worms on wildlife and to explore the dynamics of parasite-host relationships.


Praziquantel (CAS 55268-74-1) References

  1. Praziquantel for the treatment of schistosomiasis: its use for control in areas with endemic disease and prospects for drug resistance.  |  Doenhoff, MJ. and Pica-Mattoccia, L. 2006. Expert Rev Anti Infect Ther. 4: 199-210. PMID: 16597202
  2. Resolution of praziquantel.  |  Woelfle, M., et al. 2011. PLoS Negl Trop Dis. 5: e1260. PMID: 21949890
  3. Efficacy of praziquantel and artemisinin derivatives for the treatment and prevention of human schistosomiasis: a systematic review and meta-analysis.  |  Liu, R., et al. 2011. Parasit Vectors. 4: 201. PMID: 22004571
  4. Susceptibility or resistance of praziquantel in human schistosomiasis: a review.  |  Wang, W., et al. 2012. Parasitol Res. 111: 1871-7. PMID: 23052781
  5. Praziquantel for Schistosomiasis: Single-Drug Metabolism Revisited, Mode of Action, and Resistance.  |  Vale, N., et al. 2017. Antimicrob Agents Chemother. 61: PMID: 28264841
  6. Medicinal chemistry of antischistosomal drugs: Praziquantel and oxamniquine.  |  da Silva, VBR., et al. 2017. Bioorg Med Chem. 25: 3259-3277. PMID: 28495384
  7. Acting beyond 2020: better characterization of praziquantel and promising antischistosomal leads.  |  Panic, G. and Keiser, J. 2018. Curr Opin Pharmacol. 42: 27-33. PMID: 30077117
  8. Praziquantel: An Enigmatic, Yet Effective, Drug.  |  Timson, DJ. 2020. Methods Mol Biol. 2151: 1-8. PMID: 32451991
  9. Synthesis and therapeutic delivery approaches for praziquantel: a patent review (2010-present).  |  Adekiya, TA., et al. 2021. Expert Opin Ther Pat. 31: 851-865. PMID: 33832392
  10. Praziquantel use in aquaculture - Current status and emerging issues.  |  Norbury, LJ., et al. 2022. Int J Parasitol Drugs Drug Resist. 18: 87-102. PMID: 35220160
  11. Recent trends in praziquantel nanoformulations for helminthiasis treatment.  |  Mengarda, AC., et al. 2022. Expert Opin Drug Deliv. 19: 383-393. PMID: 35264036
  12. Development of Praziquantel sulphonamide derivatives as antischistosomal drugs.  |  Angeli, A., et al. 2022. J Enzyme Inhib Med Chem. 37: 1479-1494. PMID: 35635137
  13. Praziquantel: An update on the mechanism of its action against schistosomiasis and new therapeutic perspectives.  |  Nogueira, RA., et al. 2022. Mol Biochem Parasitol. 252: 111531. PMID: 36375598
  14. Genotoxic activity of praziquantel.  |  Montero, R. and Ostrosky, P. 1997. Mutat Res. 387: 123-39. PMID: 9439709

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Praziquantel, 5 g

sc-204857
5 g
$84.00