ACCÈS RAPIDE AUX LIENS
PINX1 (PIN2/TRF1-interacting protein X1), also known as LPTL or LPTS (liver-related putative tumor suppressor), is a ubiquitously expressed protein that localizes to nucleoli and telomere speckles. PINX1 contains one G-patch domain and one telomeric inhibiting domain (TID) at its C-terminus. PINX1 interacts with the telomere protein TRF1 and the telomerase reverse transcriptase TERT. The TID domain of PINX1 specifically interacts with TERT and functions to inhibit its activity, thus participating in the regulation of telomerase activity. Overexpression of PINX1 leads to shortened telomeres, further supporting an inhibitory role of PINX1 on telomerase activity. The depletion of PINX1 significantly increases telomerase activity and may lead to tumorigenicity of cancer cells. This suggests that PINX1 acts as a tumor suppressor and can inhibit cell proliferation. In addition, PINX1 is involved in nucleolar RNA maturation.
Informations pour la commande
Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps PINX1 (A-9) | sc-376588 | 200 µg/ml | $316.00 | |||
PINX1 (A-9): m-IgG Fc BP-HRP Kit | sc-540603 | 200 µg Ab; 10 µg BP | $354.00 | |||
PINX1 (A-9): m-IgG1 BP-HRP Kit | sc-542237 | 200 µg Ab; 20 µg BP | $354.00 | |||
PINX1 (A-9) peptide neutralisant | sc-376588 P | 100 µg/0.5 ml | $68.00 |