Peptidoglycan recognition protein-L (PGRP-L) is a pattern recognition molecule consisting of 576 amino acid residues. It is the longest and most widely expressed member of the PGRP family. PGRP-L is a Zn2+-dependent protein with N-acetylmuramyl-L-alanine-amidase activity that digests peptidoglycan. PGRP-L can form a homodimer and may dimerize with other PGRP proteins. It is a secreted serum protein but is also expressed as a transmembrane protein in liver parenchymal cells binding peptidoglycan and Gram-positive bacteria. PGRP-L deficient mice exhibit slightly lower levels of IL-6 and TNFα but exhibit no obvious phenotypic abnormalities. This suggests that PGRP-L may play a minor role in innate immune functions. In addition, PGRP-L may be a key player in the activation of Nod1, an intracellular pattern recognition protein.
Informations pour la commande
Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps PGRP-L (A-5) | sc-166825 | 200 µg/ml | $316.00 | |||
PGRP-L (A-5): m-IgG2a BP-HRP Kit | sc-546033 | 200 µg Ab; 10 µg BP | $354.00 |