Pegasus Antibody (1B6): sc-517137

Pegasus Antibody (1B6) is a mouse monoclonal IgG2a kappa light chain antibody that detects the Pegasus protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-Pegasus antibody (1B6) is available as the non-conjugated form. Pegasus protein, also known as zinc finger protein Ikaros 5, is a crucial transcriptional repressor composed of 419 amino acids and is primarily localized in the nucleus, where Pegasus protein plays a significant role in regulating gene expression. Pegasus protein binds to the 5′GNNTGTNG-3′ DNA core sequence, utilizing five C2H2-type zinc finger domains, which are essential for both DNA binding and the formation of homodimers and heterodimers with other Ikaros family members. Pegasus protein′s ability to interact with these family members, such as Ikaros and Helios, is vital for the modulation of transcriptional activity in response to cellular signaling events, particularly during T-cell activation. Pegasus protein is expressed in various tissues, including the kidney, heart, skeletal muscle, brain, and liver, highlighting Pegasus protein′s importance in diverse biological processes. Using Pegasus (1B6) antibody in research can provide valuable insights into the regulatory mechanisms of gene expression and the functional dynamics of the Ikaros family in hematopoietic development and immune responses.

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Pegasus Antibody (1B6) References:

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2. Non-DNA-binding Ikaros isoform gene expressed in adult B-precursor acute lymphoblastic leukemia.  |  Nishii, K., et al. 2002. Leukemia. 16: 1285-92. PMID: 12094252
3. Early hematopoietic lineage restrictions directed by Ikaros.  |  Yoshida, T., et al. 2006. Nat Immunol. 7: 382-91. PMID: 16518393
4. Human Ikaros function in activated T cells is regulated by coordinated expression of its largest isoforms.  |  Ronni, T., et al. 2007. J Biol Chem. 282: 2538-47. PMID: 17135265
5. Ikaros and chromatin regulation in early hematopoiesis.  |  Ng, SY., et al. 2007. Curr Opin Immunol. 19: 116-22. PMID: 17307348
6. Ikaros is regulated through multiple histone modifications and deoxyribonucleic acid methylation in the pituitary.  |  Zhu, X., et al. 2007. Mol Endocrinol. 21: 1205-15. PMID: 17341593
7. Recruitment of ikaros to pericentromeric heterochromatin is regulated by phosphorylation.  |  Gurel, Z., et al. 2008. J Biol Chem. 283: 8291-300. PMID: 18223295
8. Long-term antiplatelet therapy following myocardial infarction: implications of PEGASUS-TIMI 54.  |  Parker, WA. and Storey, RF. 2016. Heart. 102: 783-9. PMID: 26857211
9. [PEGASUS or COMPASS? A guide for a wise clinical choice.].  |  Brunetti, ND., et al. 2019. Recenti Prog Med. 110: 518-520. PMID: 31808430
10. Pegcetacoplan versus eculizumab in patients with paroxysmal nocturnal haemoglobinuria (PEGASUS): 48-week follow-up of a randomised, open-label, phase 3, active-comparator, controlled trial.  |  de Latour, RP., et al. 2022. Lancet Haematol. 9: e648-e659. PMID: 36055332
11. Efficacy and Safety of Rilzabrutinib in Pemphigus: PEGASUS Phase 3 Randomized Study.  |  Murrell, DF., et al. 2024. J Invest Dermatol. 144: 1762-1771.e6. PMID: 38493933
12. Hemolysis events in the phase 3 PEGASUS study of pegcetacoplan in patients with paroxysmal nocturnal hemoglobinuria.  |  Peffault de Latour, R., et al. 2024. Blood Adv. 8: 2718-2725. PMID: 38593241