ACCÈS RAPIDE AUX LIENS
The proton-coupled amino acid transporter family consists of four family members, namely PAT1, PAT2, PAT3 and PAT4, all of which mediate the 1:1 symport of protons and small neutral amino acids and derivatives across both intracellular and plasma membranes. Substrates for the PAT family members include L- and D-proline, glycine and L-alanine, 3-amino-1-propanesulfonic acid, L-azetidine-2-carboxylic acid and cis-4-hydroxy-D-proline. PAT1 expression is high in intestine and brain where it localizes to the brush border membrane, thereby allowing PAT1 to serve as a novel route for oral drug delivery. PAT2 shows high expression in spinal cord and brain, while PAT3 expression is found in testis. PAT4 is a multi-pass membrane protein that is expressed as two alternatively spliced isoforms. All four PAT family members contain three conserved histidine residues with His-55 found to be essential for catalytic activity of PAT1.
Informations pour la commande
Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps PAT2 (O-62) | sc-130490 | 100 µg/ml | $333.00 |