pan CEA Antibody (H-8): sc-48364

pan CEA Antibody (H-8) is a mouse monoclonal IgG1 kappa light chain antibody that detects pan CEA protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). anti-pan CEA antibody (H-8) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Carcinoembryonic antigen (CEA) is a critical tumor marker widely utilized in serum immunoassays for carcinoma detection, playing a significant role in cancer diagnosis and monitoring. pan CEA (H-8) antibody targets proteins primarily located on the cell surface, where CEA is involved in cell adhesion processes essential for maintaining tissue architecture and facilitating communication between cells. This localization is particularly important in tumor biology, as alterations in cell adhesion can lead to increased tumor invasiveness and metastasis. CEACAM proteins, including pan CEA, are encoded by genes clustered on the long arm of chromosome 19, and expression levels can provide valuable insights into the progression of various malignancies.

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pan CEA Antibody (H-8) References:

1. Augmenting transgene expression from carcinoembryonic antigen (CEA) promoter via a GAL4 gene regulatory system.  |  Koch, PE., et al. 2001. Mol Ther. 3: 278-83. PMID: 11273768
2. Keratin and carcinoembryonic antigen (CEA) in human melanoma cells.  |  Om, A., et al. 1991. Virchows Arch B Cell Pathol Incl Mol Pathol. 61: 81-7. PMID: 1720588
3. Haplotypic diversity in human CEACAM genes: effects on susceptibility to meningococcal disease.  |  Callaghan, MJ., et al. 2008. Genes Immun. 9: 30-7. PMID: 17960155
4. The CEACAM1 transmembrane domain, but not the cytoplasmic domain, directs internalization of human pathogens via membrane microdomains.  |  Muenzner, P., et al. 2008. Cell Microbiol. 10: 1074-92. PMID: 18081725
5. The CEACAM1-mediated apoptosis pathway is activated by CEA and triggers dual cleavage of CEACAM1.  |  Nittka, S., et al. 2008. Oncogene. 27: 3721-8. PMID: 18278069
6. CEACAM1 dynamics during neisseria gonorrhoeae suppression of CD4+ T lymphocyte activation.  |  Lee, HS., et al. 2008. J Immunol. 180: 6827-35. PMID: 18453603
7. Altered splicing of CEACAM1 in breast cancer: identification of regulatory sequences that control splicing of CEACAM1 into long or short cytoplasmic domain isoforms.  |  Gaur, S., et al. 2008. Mol Cancer. 7: 46. PMID: 18507857
8. CEACAM1, a SOX9 direct transcriptional target identified in the colon epithelium.  |  Zalzali, H., et al. 2008. Oncogene. 27: 7131-8. PMID: 18794798
9. CEACAM1 inhibits Toll-like receptor 2-triggered antibacterial responses of human pulmonary epithelial cells.  |  Slevogt, H., et al. 2008. Nat Immunol. 9: 1270-8. PMID: 18836450
10. Cytokine-induced CEACAM1 expression on keratinocytes is characteristic for psoriatic skin and contributes to a prolonged lifespan of neutrophils.  |  Rahmoun, M., et al. 2009. J Invest Dermatol. 129: 671-81. PMID: 18843289
11. Interdependency of CEACAM-1, -3, -6, and -8 induced human neutrophil adhesion to endothelial cells.  |  Skubitz, KM. and Skubitz, AP. 2008. J Transl Med. 6: 78. PMID: 19077207
12. Tissue demonstration of carcinoembryonic antigen (CEA) in ulcerative colitis.  |  Isaacson, P. 1976. Gut. 17: 561-7. PMID: 964689

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-pan CEA Antibody (H-8) has 4 citations in a variety of scientific publications.

Primary antibodies like Anti-pan CEA Antibody (H-8) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

pan CEA Antibody (H-8) Specifications

Alternate Product Name: pan CEA

Product Clone Name: H-8

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 35-334

Epitope Target: CEA (carcinoembryonic antigen)

Epitope Species: human

Product Reactivity/Detection: pan CEA

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 4 citations in various scientific publications

Available Conjugates/Forms for pan CEA Antibody (H-8): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin