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MAP (mitogen-activated protein) kinases play a significant role in many biological processes, including cell adhesion and spreading, cell differentiation and apoptosis. p38 alpha MAPK14, p38 beta MAPK11 and p38 gamma MAPK12 each contain one protein kinase domain and belong to the MAP kinase family. Expressed in different areas throughout the body with common expression patterns in heart, p38 proteins use magnesium as a cofactor to catalyze the ATP-dependent phosphorylation of target proteins. Via their catalytic activity, p38 alpha MAPK14, p38 beta MAPK11 and p38 gamma MAPK12 are involved in a variety of events throughout the cell, including signal transduction pathways, cytokine production and cell proliferation and differentiation. The p38 proteins are subject to phosphoryation on Thr and Tyr residues, an event which is thought to activate the phosphorylated protein.
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Informations pour la commande
Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps p38 gamma MAPK12 (E-11) | sc-365487 | 200 µg/ml | $316.00 | |||
p38 gamma MAPK12 (E-11): m-IgG3 BP-HRP Kit | sc-550429 | 200 µg Ab; 40 µg BP | $354.00 | |||
p38 gamma MAPK12 (E-11) peptide neutralisant | sc-365487 P | 100 µg/0.5 ml | $68.00 |