p19 INK4D/CDKN2D Antibody (D-9): sc-271176

p19 INK4D Antibody (D-9) is a mouse monoclonal IgG1 antibody that detects p19 INK4D in mouse and rat samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). p19 INK4D plays a crucial role in regulating the cell cycle by specifically inhibiting the kinase activities of cyclin-dependent kinases Cdk4 and Cdk6, which are essential for the transition from the G1 phase to the S phase of the cell cycle. This inhibition helps prevent uncontrolled cell proliferation, a hallmark of cancer. p19 INK4D expression reaches maximum levels during the S phase, and overexpression can lead to G1 arrest, highlighting potential tumor suppressor properties. The gene encoding p19 INK4D is located on chromosome 9p21.3, a region frequently associated with chromosomal abnormalities in various human tumors, further underscoring significance in cancer biology. Anti-p19 INK4D antibody (D-9) serves as an invaluable tool for researchers studying cell cycle regulation and mechanisms underlying tumorigenesis.

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p19 INK4D/CDKN2D Antibody (D-9) References:

1. Comparison of the effectiveness of adenovirus vectors expressing cyclin kinase inhibitors p16INK4A, p18INK4C, p19INK4D, p21(WAF1/CIP1) and p27KIP1 in inducing cell cycle arrest, apoptosis and inhibition of tumorigenicity.  |  Schreiber, M., et al. 1999. Oncogene. 18: 1663-76. PMID: 10208428
2. The cyclin-dependent kinase inhibitors p18INK4c and p19INK4d are highly expressed in CD34+ progenitor and acute myeloid leukaemic cells but not in normal differentiated myeloid cells.  |  Tschan, MP., et al. 1999. Br J Haematol. 106: 644-51. PMID: 10468852
3. Protein folding and stability of human CDK inhibitor p19(INK4d).  |  Zeeb, M., et al. 2002. J Mol Biol. 315: 447-57. PMID: 11786024
4. The immunohistochemical expression pattern of Chk2, p53, p19INK4d, MAGE-A4 and other selected antigens provides new evidence for the premeiotic origin of spermatocytic seminoma.  |  Rajpert-De Meyts, E., et al. 2003. Histopathology. 42: 217-26. PMID: 12605640
5. Polypyrimidine tract-binding protein induces p19(Ink4d) expression and inhibits the proliferation of H1299 cells.  |  Lin, S., et al. 2013. PLoS One. 8: e58227. PMID: 23536791
6. miR-125b modulates megakaryocyte maturation by targeting the cell-cycle inhibitor p19INK4D.  |  Qu, M., et al. 2016. Cell Death Dis. 7: e2430. PMID: 27763644
7. Cell cycle-independent roles of p19INK4d in human terminal erythropoiesis.  |  Han, X. and Liu, J. 2017. Chin J Cancer. 36: 22. PMID: 28228163
8. Phosphorylation-induced unfolding regulates p19INK4d during the human cell cycle.  |  Kumar, A., et al. 2018. Proc Natl Acad Sci U S A. 115: 3344-3349. PMID: 29531090
9. Examining the role of phosphorylation of p19INK4d in its stability and ubiquitination using chemical protein synthesis.  |  Msallam, M., et al. 2020. Chem Sci. 11: 5526-5531. PMID: 32874495
10. Lack of mutation in the cyclin-dependent kinase inhibitor, p19INK4d, in tumor-derived cell lines and primary tumors.  |  Zariwala, M. and Xiong, Y. 1996. Oncogene. 13: 2033-8. PMID: 8934552

The preferred p19 INK4D/CDKN2D antibody is p19 INK4D/CDKN2D Antibody (DCS-100): sc-56334.