Every item is shipped based on the best shipping method assessed for the temperature requirements of that specific item. Items are grouped and shipped together whenever
possible, and a separate shipping charge will be included for each shipping method required. Shipping charges listed below are from our US warehouses to the Contiguous US,
Alaska, Hawaii, Canada and Puerto Rico. Shipping charges for countries outside the US and Canada will be determined once order has been received
Please note: We can not ship to PO boxes
ACCÈS RAPIDE AUX LIENS
Express Blue Ice
Express Dry Ice
Animal Health Prescription Item
SHIPPING METHODS & CHARGES
Ships via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal
health products, bulky and/or heavy items
Labware ships FedEx Ground free of charge to the contiguous US
The Shc gene encodes three widely expressed proteins which act as substrates for receptors and tyrosine kinases in signal transduction pathways. Growth factor receptors with tyrosine kinase activity phosphorylate and thus modulate the function of Shc. Specifically, the tyrosine phosphorylation of Shc residues 239/240 and 317 stimulates activation of Ras/MAPK via recruitment of the Grb2-Sos complex, with Shc binding Grb2. These residues are present in all Shc isoforms. In vitro, tyrosine residues 239/240 are phosphorylated by the tyrosine kinase Src, while stimulation of hematopoietic cells with interleukin 3 (IL-3) results in Shc phosphorylation, primarily on residues Tyr 239 and Tyr 317. Similarly, insulin and EGF stimulate the phosphorylation of Shc and the subsequent binding of Shc and Grb2. Shc has a role in insulin-induced mitogenesis by competing with IRS to bind to the insulin receptor. The human Shc gene maps to chromosome 1q21.3.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.