Date published: 2026-5-8

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Oxymetazoline Hydrochloride (CAS 2315-02-8)

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Application:
Oxymetazoline Hydrochloride is is an α1-AR and α2-AR adrenergic receptor agonist.
CAS Number:
2315-02-8
Molecular Weight:
296.84
Molecular Formula:
C16H24N2O•HCl
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Oxymetazoline hydrochloride functions as a potent and selective alpha-adrenergic agonist. It acts by binding to and activating alpha-adrenergic receptors in the smooth muscle of blood vessels, leading to vasoconstriction. This results in the narrowing of blood vessels, which in turn reduces blood flow and swelling in the targeted area. At the molecular level, oxymetazoline hydrochloride′s mechanism of action involves stimulating the alpha-adrenergic receptors, leading to the activation of intracellular signaling pathways that ultimately result in smooth muscle contraction. Oxymetazoline Hydrochloride′s function in experimental applications involves its ability to induce localized vasoconstriction. Its mechanism of action at the cellular level provides insights into the mechanisms underlying vasoconstriction and its potential implications in various experimental applications.


Oxymetazoline Hydrochloride (CAS 2315-02-8) References

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  2. Construction and analytical applications of plastic membrane electrode for oxymetazoline hydrochloride.  |  Issa, YM. and Zayed, SI. 2004. Anal Sci. 20: 297-300. PMID: 15055954
  3. Simultaneous determination of triamcinolone acetonide and oxymetazoline hydrochloride in nasal spray formulations by HPLC.  |  Sudsakorn, S., et al. 2006. J Pharm Biomed Anal. 40: 1273-80. PMID: 16297589
  4. Interaction of the alpha-adrenoceptor agonist oxymetazoline with serotonin 5-HT1A, 5-HT1B, 5-HT1C and 5-HT1D receptors.  |  Schoeffter, P. and Hoyer, D. 1991. Eur J Pharmacol. 196: 213-6. PMID: 1678720
  5. Flow-injection chemiluminescence method for the determination of naphazoline hydrochloride and oxymetazoline hydrochloride.  |  Wang, NN., et al. 2009. Luminescence. 24: 178-82. PMID: 19253271
  6. The investigation of the interaction between Oxymetazoline hydrochloride and mucin by spectroscopic approaches.  |  Yu, X., et al. 2013. Spectrochim Acta A Mol Biomol Spectrosc. 103: 125-9. PMID: 23257339
  7. Oxymetazoline hydrochloride cream for facial erythema associated with rosacea.  |  Patel, NU., et al. 2017. Expert Rev Clin Pharmacol. 10: 1049-1054. PMID: 28837365
  8. Association of Oxymetazoline Hydrochloride, 0.1%, Solution Administration With Visual Field in Acquired Ptosis: A Pooled Analysis of 2 Randomized Clinical Trials.  |  Slonim, CB., et al. 2020. JAMA Ophthalmol. 138: 1168-1175. PMID: 33001144
  9. Topical Oxymetazoline Hydrochloride Cream 1% for the Treatment of Persistent Facial Erythema of Rosacea in Adults: A Comprehensive Review of Current Evidence.  |  Del Rosso, JQ. and Tanghetti, E. 2021. J Clin Aesthet Dermatol. 14: 32-37. PMID: 33841614
  10. Rapid and sensitive simultaneous separation and electrochemical detection of tetracaine hydrochloride and oxymetazoline hydrochloride in pharmaceutical formulations via core-shell reversed-phase liquid chromatography.  |  Alghamdi, H., et al. 2022. J Pharm Biomed Anal. 214: 114717. PMID: 35358771
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Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Oxymetazoline Hydrochloride, 1 g

sc-203172B
1 g
$95.00

Oxymetazoline Hydrochloride, 5 g

sc-203172
5 g
$158.00

Oxymetazoline Hydrochloride, 10 g

sc-203172C
10 g
$367.00

Oxymetazoline Hydrochloride, 25 g

sc-203172A
25 g
$612.00