Orlistat-d3
ACCÈS RAPIDE AUX LIENS
Orlistat-d3 is a compound that functions as a pancreatic lipase inhibitor in experimental applications. It works by binding to the active site of pancreatic lipase, preventing the hydrolysis of dietary fats into absorbable free fatty acids and monoglycerides. This inhibition leads to a reduction in the absorption of dietary fats, resulting in decreased caloric intake. Orlistat-d3 specifically targets the gastrointestinal tract, where it exerts its inhibitory effect on pancreatic lipase activity. By interfering with the digestion and absorption of dietary fats, Orlistat-d3 can be used to investigate the role of pancreatic lipase in lipid metabolism and energy balance. Its mechanism of action at the molecular level involves the reversible binding of the compound to the active site of pancreatic lipase, thereby impeding its enzymatic activity. This inhibition of pancreatic lipase by Orlistat-d3 can be utilized to study the physiological and metabolic consequences of impaired fat digestion and absorption in experimental models.
Orlistat-d3 Références
- La lipotoxicité provoque une défaillance multisystémique des organes et exacerbe la pancréatite aiguë en cas d'obésité. | Navina, S., et al. 2011. Sci Transl Med. 3: 107ra110. PMID: 22049070
- Sécurité d'un nouveau produit combiné pour la perte de poids contenant de l'orlistat et de l'acarbose. | Grudén, S., et al. 2021. Clin Pharmacol Drug Dev. 10: 1242-1247. PMID: 33580745
- Disposition de l'orlistat dans le jéjunum humain et effet de l'inhibition de la lipolyse sur les concentrations et la composition des sels biliaires. | Braeckmans, M., et al. 2022. Int J Pharm. 621: 121807. PMID: 35533920
Informations pour la commande
| Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Orlistat-d3, 1 mg | sc-219495 | 1 mg | $650.00 |