Nurr1 Antibody (F-5): sc-376984

Nurr1 Antibody (F-5) is a mouse monoclonal IgG2a kappa light chain antibody engineered to detect Nurr1, also known as NR4A2 or Nur-related factor 1, across mouse, rat, and human species through western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA) applications. Nurr1 monoclonal antibody (F-5) is raised against amino acids 66-262 of the mouse Nurr1 protein, ensuring precise binding to a critical region near the N-terminus. Nurr1 (F-5) antibody recognizes a nuclear receptor localized within the cell nucleus, where Nurr1 functions as a transcription factor regulating genes essential for neuronal development, the maintenance of dopaminergic neurons, and immune responses. Nuclear localization of Nurr1 is pivotal for modulating gene expression involved in neurological disorders such as Parkinson′s disease, as well as in inflammatory and immune-related conditions. anti-Nurr1 antibody (F-5) facilitates reliable detection and analysis of Nurr1 expression and activity, making this reagent an indispensable tool for researchers investigating molecular mechanisms underlying critical biological processes. Nurr1 (F-5) monoclonal antibody supports advanced studies in gene regulation and cellular function, contributing to breakthroughs in both basic and applied biomedical research. Nurr1 monoclonal antibody (F-5) ensures accurate and consistent results, enhancing understanding of nuclear receptor roles in health and disease. Available in both non-conjugated and various conjugated forms, including horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® variants, anti-Nurr1 antibody (F-5) offers versatility for diverse experimental setups.

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Nurr1 Antibody (F-5) References:

1. Identification of a new brain-specific transcription factor, NURR1.  |  Law, SW., et al. 1992. Mol Endocrinol. 6: 2129-35. PMID: 1491694
2. Nurr1, an orphan nuclear receptor with essential functions in developing dopamine cells.  |  Perlmann, T. and Wallén-Mackenzie, A. 2004. Cell Tissue Res. 318: 45-52. PMID: 15340833
3. Induction patterns of transcription factors of the nur family (nurr1, nur77, and nor-1) by typical and atypical antipsychotics in the mouse brain: implication for their mechanism of action.  |  Maheux, J., et al. 2005. J Pharmacol Exp Ther. 313: 460-73. PMID: 15615863
4. A role for the NGFI-B family in adrenal zonation and adrenocortical disease.  |  Bassett, MH., et al. 2004. Endocr Res. 30: 567-74. PMID: 15666793
5. The Critical Role of Nurr1 as a Mediator and Therapeutic Target in Alzheimer's Disease-related Pathogenesis.  |  Jeon, SG., et al. 2020. Aging Dis. 11: 705-724. PMID: 32489714
6. Medicinal Chemistry and Chemical Biology of Nurr1 Modulators: An Emerging Strategy in Neurodegeneration.  |  Willems, S. and Merk, D. 2022. J Med Chem. 65: 9548-9563. PMID: 35797147
7. Unimpaired thymic and peripheral T cell death in mice lacking the nuclear receptor NGFI-B (Nur77).  |  Lee, SL., et al. 1995. Science. 269: 532-5. PMID: 7624775
8. NOT, a human immediate-early response gene closely related to the steroid/thyroid hormone receptor NAK1/TR3.  |  Mages, HW., et al. 1994. Mol Endocrinol. 8: 1583-91. PMID: 7877627
9. Induction of NGFI-B gene expression during T cell activation. Role of protein phosphatases.  |  Garcia, I., et al. 1994. J Immunol. 153: 3417-25. PMID: 7930567
10. Involvement of JunD in transcriptional activation of the orphan receptor gene nur77 by nerve growth factor and membrane depolarization in PC12 cells.  |  Yoon, JK. and Lau, LF. 1994. Mol Cell Biol. 14: 7731-43. PMID: 7969116
11. Molecular characterization of the Nur77 orphan steroid receptor in apoptosis.  |  Winoto, A. 1994. Int Arch Allergy Immunol. 105: 344-6. PMID: 7981602
12. Endocrine and neurogenic regulation of the orphan nuclear receptors Nur77 and Nurr-1 in the adrenal glands.  |  Davis, IJ. and Lau, LF. 1994. Mol Cell Biol. 14: 3469-83. PMID: 8164692

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Nurr1 Antibody (F-5) has 19 citations in a variety of scientific publications.

Primary antibodies like Anti-Nurr1 Antibody (F-5) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Nurr1 Antibody (F-5) Specifications

Alternate Product Name: Nurr1

Product Clone Name: F-5

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 66-262

Epitope Target: Nurr1

Epitope Species: mouse

Product Reactivity/Detection: Nurr1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 19 citations in various scientific publications

Available Conjugates/Forms for Nurr1 Antibody (F-5): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin, X: TransCruz Reagent

The preferred Nurr1 antibody is Nurr1 Antibody (447C2a): sc-81345.