NUDT22 (nudix (nucleoside diphosphate linked moiety X)-type motif 22) is a member of the Nudix hydrolase family of pyrophosphatases. Nudix hydrolases contain a characteristic Nudix domain and are responsible for catalyzing the hydrolysis of nucleoside diphosphate derivatives. NUDT22 is a 303 amino acid protein that lacks the nudix box, therefore lacking hydrolase activity. The gene encoding NUDT17 maps to human chromosome 11, which makes up around 4% of human genomic DNA and is considered a gene and disease association dense chromosome. The chromosome 11 encoded Atm gene is important for regulation of cell cycle arrest and apoptosis following double strand DNA breaks. Atm mutation leads to the disorder known as ataxia-telangiectasia. The blood disorders Sickle cell anemia and β thalassemia are caused by HBB gene mutations. Wilms' tumors, WAGR syndrome and Denys-Drash syndrome are associated with mutations of the WT1 gene.
Informations pour la commande
Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps NUDT22 (B-2) | sc-393409 | 200 µg/ml | $316.00 | |||
NUDT22 (B-2) peptide neutralisant | sc-393409 P | 100 µg/0.5 ml | $68.00 |