ACCÈS RAPIDE AUX LIENS
Neurotensin (NT) initiates an intracellular response by interacting with the G protein-coupled receptors NTR1 (NTS1 receptor, high affinity NTR) and NTR2 (NTS2 receptor, levocabastine-sensitive neurotensin receptor), and the type I receptor NTR3 (NTS3 receptor, sortilin-1, Gp95). NT has a wide distribution in regions of the brain and in peripheral tissues where NT receptors can contribute to hypotension, hyperglycemia, hypothermia, antinociception and regulation of intestinal motility and secretion. HL-60 cells express NTR1, which can couple to Gq, Gi/o, or Gs. Alternative splicing of rat NTR2 can generate a 5-transmembrane domain variant isoform that is co-expressed with the full-length NTR2 throughout the brain and spinal cord. NTR3 activation in the murine microglial cell line N11 induces MIP-2, MCP-1, IL-1β and TNFα in an ERK1/2 and Akt kinase-dependent manner.
Alexa Fluor® est une marque déposée de Molecular Probes Inc., OR., USA
LI-COR® et Odyssey® sont marques déposées de LI-COR Biosciences
Informations pour la commande
Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps NTR3 (E-9) | sc-376576 | 200 µg/ml | $316.00 | |||
NTR3 (E-9): m-IgG Fc BP-HRP Kit | sc-540600 | 200 µg Ab; 10 µg BP | $354.00 | |||
NTR3 (E-9): m-IgG2a BP-HRP Kit | sc-546934 | 200 µg Ab; 10 µg BP | $354.00 |