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NOP17 (nucleolar protein 17), also known as PIH1D1, is a phylogenetically conserved protein essential for efficient processing of pre-rRNA through its association with a class of small nucleolar RNAs (snoRNAs) during ribosomal biogenesis. SnoRNAs are associated in ribonucleoprotein particles localized to the nucleolus. NOP17 is a 290 amnio acid unstable protein that is stabilized through an interaction with HSP 90α/β. NOP17 interacts with a core box C/D snoRNP protein Nop58, indicating a function of NOP17 in mediating the nucleolar retention or proper assembly of the box C/D snoRNP. A mutation in NOP17 gene may lead to a temperature-sensitive phenotype along with delocalization of key NOP proteins that are essential for snoRNP assembly.
Informations pour la commande
Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps NOP17 (G-10) | sc-398517 | 200 µg/ml | $316.00 | |||
NOP17 (G-10) peptide neutralisant | sc-398517 P | 100 µg/0.5 ml | $68.00 |