The mammalian homologs of the Ced-4 proteins, Apaf-1 (Ced-4), NOD1 (CARD4), and NOD2 contain a caspase recruitment domain (CARD) and a putative nucleotide binding domain, signified by a consensus Walker's A box (P-loop) and B box (Mg2+-binding site). NOD1 contains a putative regulatory domain and multiple leucine-rich repeats. NOD1 is a member of a growing family of intracellular proteins which share structural homology to the apoptosis regulator Apaf-1. NOD1 associates with the CARD-containing kinase RICK and activates NFkB. The self-association of NOD1 mediates proximity of RICK and the interaction of RICK with IKKg. In addition, NOD1 binds to multiple caspases with long prodomains, but specifically activates caspase-9 and promotes caspase-9-induced apoptosis. NOD2 is composed of two N-terminal CARDs, a nucleotide-binding domain, and multiple C-terminal leucine-rich repeats. The expression of NOD2 is highly restricted to monocytes, and activates NFkB in response to bacterial lipopoly-saccharides.
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Informations pour la commande
Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps NOD1 (C-9) | sc-377111 | 200 µg/ml | $316.00 | |||
NOD1 (C-9): m-IgG Fc BP-HRP Kit | sc-538021 | 200 µg Ab; 10 µg BP | $354.00 | |||
NOD1 (C-9): m-IgGκ BP-HRP Kit | sc-535541 | 200 µg Ab; 40 µg BP | $354.00 | |||
NOD1 (C-9): m-IgG1 BP-HRP Kit | sc-545488 | 200 µg Ab; 20 µg BP | $354.00 |