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The activation of signal transduction pathways by growth factors, hormones and neurotransmitters is mediated through two closely related MAP kinases, p44 and p42, designated extracellular-signal related kinase 1 (ERK 1) and ERK 2, respectively. ERK proteins are regulated by dual phosphorylation at specific tyrosine and threonine sites mapping within a characteristic Thr-Glu-Tyr motif. Phosphorylation at both Thr 183 and Tyr 185 is required for full enzymatic activation. In response to activation, MAP kinases phosphorylate downstream components on serine and threonine. Nlk, or nemo-like kinase, is a murine homolog of the Drosophila nemo (nmo) gene. Nlk and Nmo have sequence homology to both the ERK MAP kinases and the cyclin dependent kinases. Nlk is a nuclear protein with the ability to autophosphorylate.
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Informations pour la commande
Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps Nlk (H-2) | sc-271323 | 200 µg/ml | $316.00 | |||
Nlk (H-2): m-IgGκ BP-HRP Kit | sc-534927 | 200 µg Ab; 40 µg BP | $354.00 | |||
Nlk (H-2): m-IgG2b BP-HRP Kit | sc-549317 | 200 µg Ab; 10 µg BP | $354.00 | |||
Nlk (H-2) peptide neutralisant | sc-271323 P | 100 µg/0.5 ml | $68.00 |