Nkx-2.5, which is also designated cardiac specific homeobox protein (Csx), is a homeodomain-containing nuclear transcription protein of the Nkx-2 gene family. These transcriptional activators, which include thyroid transcription factor-1 (TTF-1), regulate the expression of tissue specific genes and are required for maintaining the differentiated phenotypes of various lineages. Nkx-2.5 is a homolog to the tinman protein expressed in Drosophila, and is essential for normal cardiovascular development. Expression of Nkx-2.5 during cardiomyogenesis is required for cardiac septation, in which a single atrium and ventricle are separated into four chambers. During embryonic development, Nkx-2.5 is also expressed in the foregut, thyroid, spleen and stomach, while in the adult expression is predominantly restricted to the heart. Mutations that disrupt Nkx-2.5 can result in atrial-septal defects, embryonic lethality and congenital heart disease.
Informations pour la commande
Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps Nkx-2.5 (F-2) | sc-365207 | 200 µg/ml | $316.00 | |||
Nkx-2.5 (F-2): m-IgGλ BP-HRP Kit | sc-522163 | 200 µg Ab, 40 µg BP | $354.00 | |||
Anticorps Nkx-2.5 (F-2) X | sc-365207 X | 200 µg/0.1 ml | $316.00 |