nitrated alpha Synuclein Antibody (Syn514): sc-32279

Nitrated α-synuclein Antibody (Syn514) is a mouse monoclonal IgG1 kappa light chain antibody engineered to detect oxidized α-synuclein, also known as SNCA or NACP, across mouse, rat, and human species using western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF) techniques. Nitrated α-synuclein monoclonal antibody (Syn514) targets oxidized α-synuclein, a post-translationally modified form that plays a significant role in neurodegenerative diseases. α-synuclein (Syn514) antibody recognizes an intrinsically disordered protein that can transition between various structural conformations, including unfolded states and alpha-helical structures upon membrane binding, as well as beta-sheet-rich fibrils during pathological aggregation. These structural dynamics are crucial for normal function in synaptic vesicle trafficking and neurotransmitter release, which are essential for maintaining neuronal communication and plasticity. However, nitration of α-synuclein alters structure, promoting aggregation and contributing to the formation of Lewy bodies, a hallmark of Parkinson′s disease, as well as involvement in Alzheimer′s disease pathology. Understanding these structural changes is vital for elucidating the mechanisms underlying these debilitating neurodegenerative disorders. Anti-nitrated α-synuclein antibody (Syn514) facilitates precise detection of oxidized α-synuclein, enabling researchers to investigate molecular alterations and aggregation processes associated with disease progression. Nitrated α-synuclein (Syn514) monoclonal antibody is an invaluable tool for studying structural and functional implications of α-synuclein modifications, supporting the development of therapeutic strategies aimed at mitigating protein aggregation and preserving neuronal health.

The preferred alpha Synuclein antibody is alpha Synuclein Antibody (211): sc-12767.