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NIPP1 (nuclear inhibitor of protein phosphatase 1) is a putative transcription regulator that may be involved in pre-mRNA splicing and cell proliferation. NIPP1 contains a nuclear signaling region named FHA (forkhead-associated) domain. The FHA domain has been associated with protein kinases and transcription factors. The NIPP1 locus encodes for three different isoforms termed α, β and γ due to alternative splicing events. The isoforms exhibit RNA binding activity and also act as phophatase inhibitors. The γ isoform is believed to be a magnesium-dependent endoribonuclease that is responsible for cleaving RNA strands. It is mainly found in B cells and T lymphocytes. The α and β isoforms are localized in the brain and kidney. Inactivation of NIPP1 is accom-plished by the phosphorylation of Ser 199 or Ser 204. NIPP1 interacts with proteins CDc5L, SAP 155, MELK and EED.
Informations pour la commande
Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps NIPP1 (B-4) | sc-271749 | 200 µg/ml | $316.00 | |||
NIPP1 (B-4): m-IgG Fc BP-HRP Kit | sc-540261 | 200 µg Ab; 10 µg BP | $354.00 | |||
NIPP1 (B-4): m-IgG1 BP-HRP Kit | sc-542008 | 200 µg Ab; 20 µg BP | $354.00 | |||
NIPP1 (B-4) peptide neutralisant | sc-271749 P | 100 µg/0.5 ml | $68.00 |