Anticorps neurolysin (C-4): sc-398613

Oligopeptidases are endopeptidases that act only on smaller polypeptides or oligopeptides. These enzymes are believed to influence biological functions that include the modification or destruction of peptide messenger molecules. Oligopeptidases have few naturally occurring inhibitors and possess a distinct specificity that prevents them from interacting with the ubiquitous protease inhibitor, alpha 2-macroglobulin. Neuropeptidases are oligopeptidases that modify the activity of small peptide neurotransmitters and neurohormones. The neuropeptidase neurolysin is a zinc dependent metallopeptidase that acts only on short peptides and accepts a variety of cleavage-site sequences. The connecting loop regions of the five-stranded beta-sheet and the two active site helices are extended in neurolysin and may account for the ability of the enzyme to cleave a variety of sequences. Neurolysin is ubiquitously expressed within brain and specifically localizes to neuronal perikarya in rat brain.

L'anticorps neurolysin préféré est l'Anticorps neurolysin (B-3): sc-398420.