neurocan Antibody (2Q174): sc-58551

Neurocan Antibody (2Q174) is a mouse monoclonal IgG1 antibody that detects neurocan in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. Neurocan is a crucial glycoprotein primarily synthesized by neurons, playing a significant role in the extracellular matrix of the central nervous system. Anti-neurocan antibody (2Q174) recognizes a protein consisting of 1,257 amino acids that undergoes proteolytic processing in the adult central nervous system, resulting in an N-terminal fragment localizing to the cytoplasm of glial cells. This processing suggests a functional shift in neurocan′s role as the brain matures. Neurocan interacts with various components of the central nervous system matrix, including heparin, Tenascin-R, HB-GAM, and NCAM, indicating involvement in axon guidance and neurite growth. Expression increases significantly in adults, particularly in the glial scar following cortical injury, highlighting potential roles in response to neural damage and repair mechanisms. Neurocan (2Q174) antibody serves as an essential tool for researchers studying neurodevelopment, neural injury, and the dynamics of the extracellular matrix in the central nervous system.

The preferred neurocan antibody is neurocan Antibody (650.24): sc-33663.