Anticorps Neuregulin-2 (H-8): sc-390646

The ErbB/HER family of receptor tyrosine kinases consists of four receptors that bind a large number of growth factor ligands sharing an epidermal growth factor-(EGF)-like motif. The neuregulins (NRGs) are a diverse family of proteins that arise by alternative splicing from a single gene. These proteins play an important role in controlling the growth and differentiation of glial, epithelial and muscle cells. Whereas ErbB-1 binds seven different ligands whose prototype is EGF, the four families of neuregulins activate ErbB-3 and/or ErbB-4. Neuregulin-1 (also known as heregulin) has diverse functions in neural development, one of which is to upregulate the expression of acetylcholine receptors at muscle fibers during the formation of neuromuscular junctions. Neuregulin-2 exhibits a distinct expression pattern in adult brain and developing heart. Neuregulin-3 is expressed in cell lines derived from breast cancer and is a potential regulator of normal and malignant breast epithelial cells. Neuregulin-4 is detected in the adult pancreas and weakly in muscle.

L'anticorps Neuregulin-2 préféré est l'Anticorps Neuregulin-2 (A-12): sc-398594.