Netrin G1 and netrin G2, also referred to as laminet-1 and laminet-2, are membrane bound axon guidance molecules involved in synaptic formation and maintenance. They comprise a subgroup within the UNC-6/netrin family. Both genes have been associated with schizophrenia involving single nucleotide polymorphisms. They are both expressed in the brain but G1 is most predominantly expressed in the thalamus and G2 is most predominantly expressed in the cortex. These two proteins differ from classical netrins by their failure to bind netrin receptors, the presence of a glycosyl phosphatidylinositol membrane anchor, and the generation of multiple isoforms. Netrin G1 has at least nine isoforms, all of which are expressed in adult brain. Isoforms G1a, c, d, and e are also expressed in fetal brain. G1c and G1d are the most highly expressed netrin G1 isoforms. Netrin G1 is involved in NMDA receptor function and may play a role in Rett syndrome (RTT), atypical autism, epilepsy and mental retardation.
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Informations pour la commande
Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps netrin G1 (H-4) | sc-393665 | 200 µg/ml | $316.00 | |||
netrin G1 (H-4): m-IgG Fc BP-HRP Kit | sc-538276 | 200 µg Ab; 10 µg BP | $354.00 | |||
netrin G1 (H-4): m-IgGκ BP-HRP Kit | sc-535854 | 200 µg Ab; 40 µg BP | $354.00 | |||
netrin G1 (H-4): m-IgG1 BP-HRP Kit | sc-545619 | 200 µg Ab; 20 µg BP | $354.00 |