Anticorps NDV HN (HN4a): sc-53561

Newcastle disease virus (NDV) is a negative-sense single-stranded RNA virus which causes Newcastle disease, a highly contagious zoonotic bird disease affecting many domestic and wild avian species. Transmission occurs by exposure to fecal and other excretions from infected birds and replication takes place in the cytoplasm of the host cell. NDV HN (hemagglutinin neuraminidase) is one of eight proteins encoded by the NDV genome. NDV HN is glycosylated and functions as a component of the external envelope, responsible for the binding of NDV to host cells. More specifically, NDV HN attaches to the sialic acid-containing receptors on target cells and causes an upregulation in the host cell expression of TRAIL, death receptors (DRs) and IFN-α. Once bound, the viral and cell-surface membranes fuse through a process regulated by the NDV F protein. Both NDV HN and NDV F proteins promote the infection of neighboring cells and are therefore involved in the viral infectivity and virulence of NDV.

L'anticorps NDV HN préféré est l'Anticorps NDV HN (HN14f): sc-53562.