NDUFV2 Antibody (H-7): sc-515558

NDUFV2 Antibody (H-7) is a mouse monoclonal IgG3 antibody that detects NDUFV2 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). NDUFV2, also known as NADH-ubiquinone oxidoreductase 24 kDa subunit, is a crucial component of mitochondrial complex I, which is the first and largest enzyme in the electron transport chain responsible for oxidative phosphorylation. This 249 amino acid protein plays a vital role in the catalytic activity of the complex by facilitating the transfer of electrons from NADH, produced during the Krebs cycle, to ubiquinone, thereby initiating a series of electron transfers that ultimately lead to the reduction of oxygen to water. Proper functioning of NDUFV2 is essential for maintaining cellular energy production, and defects in NDUFV2 can contribute to various myopathies and neuropathies. Furthermore, emerging research indicates that polymorphisms in the gene encoding NDUFV2 may serve as genetic risk factors for psychiatric conditions such as bipolar disorder and schizophrenia, highlighting NDUFV2′s significance not only in mitochondrial function but also in neuropsychiatric health. Anti-NDUFV2 antibody (H-7) is therefore an invaluable tool for researchers investigating NDUFV2′s role in both mitochondrial biology and disease implications.

The preferred NDUFV2 antibody is NDUFV2 Antibody (F-5): sc-271620.