Anticorps NASP (A-6): sc-398379

Histones, the chief components of chromatin, are required for the formation of core nucleosomes around which DNA can wind and they play an essential role in DNA condensation and gene regulation. The transport of histones to the nucleus is crucial to ensuring proper nucleosome assembly and, ultimately, DNA replication. NASP (nuclear autoantigenic sperm protein) is a 788 amino acid protein that localizes to both the nucleus and the cytoplasm and contains three TPR repeats. Expressed as multiple alternatively-spliced isoforms, one of which is testis- and sperm-specific (tNASP) and the other expressed in somatic cells (sNASP), NASP functions as a Histone H1 binding protein that mediates histone transport to the nucleus and is required for normal cell cycle progression and cellular proliferation. Due to its testicular expression and important role in DNA replication and cell cycle events, NASP is necessary for spermatogenesis and normal development. Upon DNA damage, NASP may be phosphorylated by ATM or ATR.

L'anticorps NASP préféré est l'Anticorps NASP (A-7): sc-514669.