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N-type calcium channels are localized in high density presynaptic nerve N-type calcium channels are localized in high density presynaptic nerve terminals and are crucial elements in neuronal excitation-secretion coupling. Peripherally distributed N-type Ca++ channel plays a key role in cardiovascular regulation through autonomic nervous system. The high-voltage activated Ca++ channels that have been characterized biochemically are complexes of a pore-forming a-1 subunit; a transmembrane, disulfide-linked complex of a-2 and d subunits; an intracellular b subunit; and in some cases, a transmembrane g subunit. The a-1 subunit conducts N-type Ca++ currents, which initiate rapid synaptic transmission. In addition to mediating Ca++ entry to initiate transmitter release, N-type Ca++ channels are thought to interact directly with proteins of the synaptic vesicle docking and fusion machinery. The synaptic protein interaction sites in the intracellular loop II-III of subunit a-1B of N-type Ca++ channels bind to syntaxin, SNAP-25 and synaptotagmin.
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Informations pour la commande
Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps N-type Ca++ CP α1B (A-11) | sc-271010 | 200 µg/ml | $316.00 | |||
N-type Ca++ CP α1B (A-11): m-IgG3 BP-HRP Kit | sc-550397 | 200 µg Ab; 40 µg BP | $354.00 |