Molecular structure of N-(Methoxysuccinyl)-Ala-Ala-Pro-Val-chloromethyl ketone, CAS Number: 65144-34-5
N-(Methoxysuccinyl)-Ala-Ala-Pro-Val-chloromethyl ketone (CAS 65144-34-5)
Alternate Names:
Elastase Inhibitor III; MeOSuc-AAPV-CMK
Application:
N-(Methoxysuccinyl)-Ala-Ala-Pro-Val-chloromethyl ketone is an inhibitor of neutrophil elastase
CAS Number:
65144-34-5
Molecular Weight:
502.99
Molecular Formula:
C22H35ClN4O7
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
N-(Methoxysuccinyl)-Ala-Ala-Pro-Val-chloromethyl ketone, also known as Methoxysuccinyl-alanyl-alanyl-prolyl-valine chloromethyl ketone or MAAVP-CMK, is a chemical compound employed in peptide synthesis. Its purpose is to facilitate the bonding of two amino acids during the synthesis process. Additionally, N-(Methoxysuccinyl)-Ala-Ala-Pro-Val-chloromethyl ketone serves as an irreversible inhibitor of trypsin, an enzyme. Researchers utilize this compound to investigate the structure, function, and biological processes associated with trypsin. Furthermore, N-(Methoxysuccinyl)-Ala-Ala-Pro-Val-chloromethyl ketone aids in studying the molecular mechanisms of other proteases like chymotrypsin and elastase.
N-(Methoxysuccinyl)-Ala-Ala-Pro-Val-chloromethyl ketone (CAS 65144-34-5) References
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- Elastase from activated human neutrophils activates procarboxypeptidase R. | Kawamura, T., et al. 2002. Microbiol Immunol. 46: 225-30. PMID: 12008933
- Human neutrophil elastase releases a ligand-binding fragment from the 75-kDa tumor necrosis factor (TNF) receptor. Comparison with the proteolytic activity responsible for shedding of TNF receptors from stimulated neutrophils. | Porteu, F., et al. 1991. J Biol Chem. 266: 18846-53. PMID: 1655765
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- Peptide conjugation to an in vitro-selected DNA ligand improves enzyme inhibition. | Lin, Y., et al. 1995. Proc Natl Acad Sci U S A. 92: 11044-8. PMID: 7479933
- Inhibition of crevicular fluid neutrophil elastase by alpha 1-antitrypsin in periodontal health and disease. | Smith, QT., et al. 1994. Arch Oral Biol. 39: 301-6. PMID: 8024494
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- Identification of an elastolytic protease in stationary phase culture filtrates of M. tuberculosis. | Rowland, SS., et al. 1997. FEMS Microbiol Lett. 151: 59-64. PMID: 9198282
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Inhibitor of:
Neutrophil Elastase, and TRIM17.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
N-(Methoxysuccinyl)-Ala-Ala-Pro-Val-chloromethyl ketone, 5 mg | sc-215426 | 5 mg | $179.00 | |||
N-(Methoxysuccinyl)-Ala-Ala-Pro-Val-chloromethyl ketone, 10 mg | sc-215426A | 10 mg | $311.00 |