Myoneurin Antibody (JB-17): sc-101082

Myoneurin Antibody (JB-17) is a mouse monoclonal IgG2a kappa light chain antibody that detects Myoneurin protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Anti-Myoneurin antibody (JB-17) is available as the non-conjugated form. Myoneurin, also known as MYNN, OSZF, SBBIZ1, or ZBTB31 (Zinc finger and BTB domain-containing protein 31), is a 610 amino acid protein that belongs to the Krüppel C2H2-type zinc-finger family and is primarily localized in the nucleus, with significant expression in the neuromuscular system. Myoneurin plays a crucial role in muscle development and regeneration through regulation of gene expression during these processes. Myoneurin expression becomes dysregulated following nerve injury, indicating importance in normal developmental events and potential implications in muscle repair mechanisms. Myoneurin features one BTB (POZ) domain and eight C2H2-type zinc fingers, which are essential for DNA-binding activity, allowing interaction with specific gene promoters and modulation of transcription. Myoneurin exists in four isoforms due to alternative splicing, which may contribute to functional diversity in various cellular contexts.

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Myoneurin Antibody (JB-17) References:

1. Myoneurin, a novel member of the BTB/POZ-zinc finger family highly expressed in human muscle.  |  Alliel, PM., et al. 2000. Biochem Biophys Res Commun. 273: 385-91. PMID: 10873615
2. A molecular epidemiological study of avian paramyxovirus type 1 (Newcastle disease virus) isolates by phylogenetic analysis of a partial nucleotide sequence of the fusion protein gene.  |  Aldous, EW., et al. 2003. Avian Pathol. 32: 239-56. PMID: 12850913
3. Neuromuscular expression of the BTB/POZ and zinc finger protein myoneurin.  |  Cifuentes-Diaz, C., et al. 2004. Muscle Nerve. 29: 59-65. PMID: 14694499
4. A molecular epidemiological investigation of isolates of the variant avian paramyxovirus type 1 virus (PPMV-1) responsible for the 1978 to present panzootic in pigeons.  |  Aldous, EW., et al. 2004. Avian Pathol. 33: 258-69. PMID: 15276997
5. Amplification of MDS1/EVI1 and EVI1, located in the 3q26.2 amplicon, is associated with favorable patient prognosis in ovarian cancer.  |  Nanjundan, M., et al. 2007. Cancer Res. 67: 3074-84. PMID: 17409414

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Myoneurin Antibody (JB-17) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-Myoneurin Antibody (JB-17) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Myoneurin Antibody (JB-17) Specifications

Alternate Product Name: Myoneurin

Product Clone Name: JB-17

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 501-611

Epitope Target: Myoneurin

Epitope Species: human

Product Reactivity/Detection: Myoneurin

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 100 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for Myoneurin Antibody (JB-17): N/A