MYBPC1 Antibody (E-6): sc-515407
- MYBPC1 Antibody (E-6) is a mouse monoclonal IgG1 κ MYBPC1 antibody provided at 200 µg/ml
- raised against amino acids 554-613 mapping within an internal region of MYBPC1 of human origin
- MYBPC1 Antibody (E-6) is recommended for detection of MYBPC1 of human origin by WB, IP, IF and ELISA
- Anti-MYBPC1 Antibody (E-6) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for MYBPC1 Antibody (E-6) for WB applications. These reagents are now offered in bundles with MYBPC1 Antibody (E-6) (see ordering information below).
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MYBPC1 Antibody (E-6) is a mouse monoclonal IgG1 kappa light chain antibody that detects MYBPC1 protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). MYBPC1 (E-6) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. MYBPC1, also known as myosin-binding protein C, slow-type or MyBP-C, is a crucial 1,141 amino acid protein characterized by three fibronectin type-III domains and seven immunoglobulin-like C2-type domains. MYBPC1 is primarily located in the striated muscle bands of vertebrates, where MYBPC1 plays a vital role in muscle contraction by interacting with myosin and modulating the activity of specific ATPases. The structural integrity and function of MYBPC1 are essential for maintaining proper muscle function, and mutations in MYBPC1 can lead to various cardiac and skeletal muscle disorders. MYBPC1 is encoded on human chromosome 12, a region associated with numerous genetic conditions, including hypochondrogenesis and Noonan syndrome, highlighting MYBPC1′s importance in both health and disease.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
MYBPC1 Antibody (E-6) References:
- The C-terminal IgI domains of myosin-binding proteins C and H (MyBP-C and MyBP-H) are both necessary and sufficient for the intracellular crosslinking of sarcomeric myosin in transfected non-muscle cells. | Welikson, RE. and Fischman, DA. 2002. J Cell Sci. 115: 3517-26. PMID: 12154082
- A novel missense mutation in the myosin binding protein-C gene is responsible for hypertrophic cardiomyopathy with left ventricular dysfunction and dilation in elderly patients. | Konno, T., et al. 2003. J Am Coll Cardiol. 41: 781-6. PMID: 12628722
- Expression of slow skeletal myosin binding C-protein in normal adult mammalian heart. | Dhoot, GK. and Perry, SV. 2005. J Muscle Res Cell Motil. 26: 143-8. PMID: 16003462
- Four and a half LIM protein 1 binds myosin-binding protein C and regulates myosin filament formation and sarcomere assembly. | McGrath, MJ., et al. 2006. J Biol Chem. 281: 7666-83. PMID: 16407297
- Localization of the binding site of the C-terminal domain of cardiac myosin-binding protein-C on the myosin rod. | Flashman, E., et al. 2007. Biochem J. 401: 97-102. PMID: 16918501
- Complete sequence of human fast-type and slow-type muscle myosin-binding-protein C (MyBP-C). Differential expression, conserved domain structure and chromosome assignment. | Weber, FE., et al. 1993. Eur J Biochem. 216: 661-9. PMID: 8375400
- Isoform-specific interaction of the myosin-binding proteins (MyBPs) with skeletal and cardiac myosin is a property of the C-terminal immunoglobulin domain. | Alyonycheva, TN., et al. 1997. J Biol Chem. 272: 20866-72. PMID: 9252413
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
MYBPC1 Antibody (E-6) | sc-515407 | 200 µg/ml | $322.00 | |||
MYBPC1 Antibody (E-6): m-IgG Fc BP-HRP Bundle | sc-531355 | 200 µg Ab; 10 µg BP | $361.00 | |||
MYBPC1 Antibody (E-6): m-IgGκ BP-HRP Bundle | sc-525026 | 200 µg Ab, 40 µg BP | $361.00 | |||
MYBPC1 Antibody (E-6): m-IgG1 BP-HRP Bundle | sc-544502 | 200 µg Ab; 20 µg BP | $361.00 | |||
MYBPC1 Antibody (E-6) AC | sc-515407 AC | 500 µg/ml, 25% agarose | $424.00 | |||
MYBPC1 Antibody (E-6) HRP | sc-515407 HRP | 200 µg/ml | $322.00 | |||
MYBPC1 Antibody (E-6) FITC | sc-515407 FITC | 200 µg/ml | $336.00 | |||
MYBPC1 Antibody (E-6) PE | sc-515407 PE | 200 µg/ml | $349.00 | |||
MYBPC1 Antibody (E-6) Alexa Fluor® 488 | sc-515407 AF488 | 200 µg/ml | $364.00 | |||
MYBPC1 Antibody (E-6) Alexa Fluor® 546 | sc-515407 AF546 | 200 µg/ml | $364.00 | |||
MYBPC1 Antibody (E-6) Alexa Fluor® 594 | sc-515407 AF594 | 200 µg/ml | $364.00 | |||
MYBPC1 Antibody (E-6) Alexa Fluor® 647 | sc-515407 AF647 | 200 µg/ml | $364.00 | |||
MYBPC1 Antibody (E-6) Alexa Fluor® 680 | sc-515407 AF680 | 200 µg/ml | $364.00 | |||
MYBPC1 Antibody (E-6) Alexa Fluor® 790 | sc-515407 AF790 | 200 µg/ml | $364.00 |