ACCÈS RAPIDE AUX LIENS
MTGR1 (CBFA2T2, ETO homologous on chromosome 20) is a nuclear protein encoded by the human CBFA2T2 gene. MTGR1 belongs to the CBFA2T family and contains one MYND-type (myeloid translocation protein 8, Nervy and DEAF-1) zinc finger and one TAFH (TBP-associated factor) domain. MTGR1 may function within the RUNX1/AML1-ETO/MTG8 chimeric protein complex which is produced from the chromosomal translocation t(8;21), which is also implicated with an acute myeloid leukemia. Within the RUNX complex, MTGR1 causes repression of RUNX1-dependent transcription and then induces G-CSF/CSF3-dependent growth. Therefore, MTGR1 is a tumor suppressor candidate for myeloid tumors containing a deletion within the 20q10-13 region. MTGR1 forms both a homo-oligomer and a hetero-oligomer with MTG8 and is ubiquitously expressed in fetal and adult tissues. CBFA2T2 deletion has been found in 10% of polycythemia vera (PV) cases.
Informations pour la commande
Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps MTGR1 (CBF5I134) | sc-81326 | 100 µg/ml | $333.00 |