The phosphorylation and dephosphorylation of proteins on serine and threonine residues is an essential means of regulating a broad range of cellular functions in eukaryotes, including cell division, homeostasis and apoptosis. A group of proteins that are intimately involved in this process are the serine/threonine (Ser/Thr) protein kinases. MSK2, also known as RPS6KA4 (ribosomal protein S6 kinase, 90kDa, polypeptide 4) or RSKB, is a 772 amino acid protein that localizes to the nucleus and contains one AGC-kinase C-terminal domain and two protein kinase domains. Using magnesium as a cofactor, MSK2 functions as a Ser/Thr kinase that is thought to play a role in the regulation of growth-factor and stress-induced transcriptional activation, specifically by catalyzing the ATP-dependent phosphorylation of target proteins. Multiple isoforms of MSK2 exist due to alternative splicing events.
Informations pour la commande
Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps MSK2 (2934C1a) | sc-130653 | 100 µg/ml | $333.00 |