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MP1 (MEK partner 1) functions as a scaffolding protein in the mitogen activated protein (MAP) kinase signaling pathway. Growth factor induced MAP kinase activation is selectively mediated by the extracellular signal-regulated kinase (ERK) cascade. This pathway is dependent on the phosphorylation of MEK-1 and its subsequent activation of ERK 1. MP1 binds to the proline-rich domain of MEK-1 and thereby potentiates the phosphorylation of MEK-1 by the activating MEK kinase B-Raf. MP1 is also able to enhance the kinase activity of MEK-1 and facilitate the phosphorylation of ERK 1. In vivo studies indicate that MP1 preferentially associates with MEK-1 and ERK 1, but not with MEK-2 or ERK 2, suggesting that MP1 and other scaffolding proteins contribute to the specificity of the kinase substrates within the MAPK pathways.
Informations pour la commande
Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps MP1 (A-12) | sc-55481 | 200 µg/ml | $316.00 | |||
MP1 (A-12): m-IgG Fc BP-HRP Kit | sc-537048 | 200 µg Ab; 10 µg BP | $354.00 | |||
MP1 (A-12): m-IgGκ BP-HRP Kit | sc-534232 | 200 µg Ab; 40 µg BP | $354.00 | |||
MP1 (A-12): m-IgG1 BP-HRP Kit | sc-544975 | 200 µg Ab; 20 µg BP | $354.00 |